The major factor that allows calcium channel blockers to be effective are ethyl groups at the 3 and 5 position, and cyclic substituents on the 4 position. Furthermore, it was found that electronegativity has no effect on blocking ability; as a result, electron donating and withdrawing groups placed on cyclic substituents don't have an effect. However, certain functional groups including bulky groups push substituents to want a position perpendicular to the dihydropyridine ring plane (Love, B.; Goodman, M. M.; Snader, K.M.; Tedeschi, R. Macko, E. J. Med. Chem. 1974, 17, 956-965). The products in this lab are ineffective because they lack an aryl substituent in the 4 position, therefor have a low
The major factor that allows calcium channel blockers to be effective are ethyl groups at the 3 and 5 position, and cyclic substituents on the 4 position. Furthermore, it was found that electronegativity has no effect on blocking ability; as a result, electron donating and withdrawing groups placed on cyclic substituents don't have an effect. However, certain functional groups including bulky groups push substituents to want a position perpendicular to the dihydropyridine ring plane (Love, B.; Goodman, M. M.; Snader, K.M.; Tedeschi, R. Macko, E. J. Med. Chem. 1974, 17, 956-965). The products in this lab are ineffective because they lack an aryl substituent in the 4 position, therefor have a low