Regardless of etiology of the bone defect, whether it’s congenital, iatrogenic, or pathologic such as tumor, trauma, infection, or necrosis, a majority of the time the treatment in adults requires segmental mandibulectomy and reconstruction of the bony defect. (Rana et al., 2011)
Although most mandibular defects in adults are treated and repaired by segmental mandibulectomy, that is not always the case in children. In children, due to their …show more content…
Whereas autologous bone grafts are still considered to be the gold standard for reconstruction of bony defects, they are associated with several disadvantages such as donor site morbidity, limited availability and the risk of unpredictable resorption (Klammert et al., 2010). There are a few issues with allogenous bone grafts and they are; improper fitting, potential infections, and immunological risks. However as we have seen with the advancement of other technologies it is expected that these issues will be resolved as more time, research, and money are invested into this product. For example a cardiac stent has gone from bare metal to drug-eluting lowering the mortality and morbidity of vascular …show more content…
The surgery would be successful in the sense of stability but most of the time the surgery was not aesthetically pleasing. Now with computer aided design and 3D printing, creating a successful graft has decreased surgery time and has increased satisfying results with strength and facial symmetry. Sadly, an issue with placing a graft using acrylic bone cement is when it cures there is an exothermic reaction which can cause the surrounding tissue to have an inflammatory response that may lead to necrosis, infection, and the possibility of the body rejecting the implant. Taking that into consideration, the most commonly used synthetic bone regeneration materials are mainly based on calcium phosphate due to their similar chemistry to the matrix of real bone (Klammert et al.,