2] is a thiazide diuretic. It works by increasing the efficacy of the kidneys in removing excess salt and water from the bloodstream, which lowers blood pressure[11]. Chemically it is RS)-2-chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide[12].. This drug is official in Indian Pharmacopoeia[3], United State Pharmacopoeia[4], British Pharmacopoeia[5] and European Pharmacopoeia[6]. This all Pharmacopoeia describes UV, RP-HPLC and TLC methods for its estimation. Literature survey reveals that UV[13] and HPLC[14, 15] methods have been reported for its determination in single and combined dosage
2] is a thiazide diuretic. It works by increasing the efficacy of the kidneys in removing excess salt and water from the bloodstream, which lowers blood pressure[11]. Chemically it is RS)-2-chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide[12].. This drug is official in Indian Pharmacopoeia[3], United State Pharmacopoeia[4], British Pharmacopoeia[5] and European Pharmacopoeia[6]. This all Pharmacopoeia describes UV, RP-HPLC and TLC methods for its estimation. Literature survey reveals that UV[13] and HPLC[14, 15] methods have been reported for its determination in single and combined dosage