However, improvements for this experiment may be to use a higher percentage of sodium bicarbonate to get rid of emulsions and hydrochloric acid, as well as use a water bath to speed up the evaporation time. Another improvement may be to use alumina as a filtering agent to get rid of the additional byproducts.
Friedel-Crafts acylation occurs as a quality control assay for steroids. The alkene groups in a 25:1 mixture of 98% acetyl chloride and 70% perchloric acid is used to distinguish between steroid analogs. A 25:1 AC/PA mixture along with AC with zinc acetate reagent were used to investigate the steroids. A color change occurs which also leads to the steroids being measured in a spectrum. Hence, Friedel-Crafts acylations using the AC/PA reagent under less hostile conditions turns out to be the speciation and quantitation of unsaturation in many natural products.
Although, the percent yield was high and crystals were not formed, this experiment was successful because three functional groups on p-methoxyacetophenone were observed on the