Introduction
Cancer happens when the cells in the body grow out of control and make tumors. This procedure is organized by biochemical in different parts of the body. (7) Breast cancer is the most common cancer among all the woman and about 5-10 percent of breast cancers are heritable. (9) Mutation in BRCA genes is responsible for 25 percent Inherent Breast cancer. Breast cancer is affected by so many risk factors. Every year about 233,000 breast cancer patients are diagnosed in the United States. Statistically speaking, approximately 12 percent of women will have breast cancer in their lifetime, with almost 5-10 percent of them carrying a harmful BRCA1 or BRCA2 mutation. (4)
There are …show more content…
Some of the racial or ethnic populations have BRCA1 and BRCA2 more common than other populations. One of these populations that has a higher prevalence in BRCA genes mutation are Ashkenazi Jewish descent in United State than other racial populations. Other than Ashkenazi Jewish Norwegian, Dutch and Icelandic peoples, in other races have more common. (1)
Considering the harmful BRCA1 and BRCA2 are rare in most of racial/ ethnicities populations who Expert think should undergo genetic testing. Most scientists believe that genomic testing should not implement on everybody and it is better to carry out only to those people who have a family history of breast or ovarian cancer. (1)
The possibility that someone with background of having a family member inherited the same harmful BRCA genes are so high. Healthcare provider and experts can use a number of screening tools for detecting mutations and assess the factors involving in breast cancer. Some of these factored that are related to having BRCA1 and BRCA2 mutations …show more content…
HMGCS1, WDR48, CTH, HMGCR are 4 different genes which had the most differential expression between non-BRCA breast cancer patients and normal people.
Conclusion
In order to have a universal screen genetic testing, we should think realistically, consider all the positive point and negative points. As we stated from other studies it does not seem to be cost efficient to take a universal genetic screen testing for BRCA1 and BRCA2. 97 percent of women which are testing for these mutations show negative result and only it increase 3-5 years of life expectancy in women with BRCA1/2 mutations which we are not indicating a low result, however, not so efficient.
Additionally, there are other cost- efficient technologies for diagnosing breast cancer in early stages like mammography with or without MRI. These techniques have the same result as breast cancer BRCA1/2 genetic testing, can diagnose breast cancer which are causing from other factors ( which are 95 percent ). BRCA1/2 are causing only 5 percent of breast cancer between the patients. Not all the people with these mutations are going to get breast cancer and 45-65 percent of BRCA1/2 carriers are getting breast cancer by age