Upon looking at the concentration levels of both osteoclast and osteoblast, there was a significant decrease in functional osteoblast, which help with new bone formation, and an accelerated increase in osteoclast formation (Kilbarger, …show more content…
Another study done by Thongchote and his associates has tested to see if running activities in mice can ameliorate bone mineral density and compensate for the microstructural differences in thalassemic mice versus thalassemic mice that do not have any running activity and are not very active. They wanted to determine the age and sex dependent changes in bone mineral density, bone mineral content, and bone microstructural changes in thalassemic mice using dual x ray absorptiometry and bone histomorphometry. They also wanted to determine if running exercises could alleviate the thalassemic induced bone loss and microstructural defect in thalassemic