Depending on the amount of 5-HT released either by EC cells, or directly applied to the organ, as in this experiment, determines level of response from the receptors (Coates et al., 2006). Little agonist and it may not be able to activate a receptor (or enough receptors for a response), and too much can lead to certain disorders and irritability. Serotonin-selective reuptake transporters (SERTs) act to inhibit the action of 5-HT by removing it from the interstitial space where it may then bind (Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse). The second messengers activated on the ileum by 5-HT is dependent on the receptors activated as listed above – excluding 5-HT3, which has a direct
Depending on the amount of 5-HT released either by EC cells, or directly applied to the organ, as in this experiment, determines level of response from the receptors (Coates et al., 2006). Little agonist and it may not be able to activate a receptor (or enough receptors for a response), and too much can lead to certain disorders and irritability. Serotonin-selective reuptake transporters (SERTs) act to inhibit the action of 5-HT by removing it from the interstitial space where it may then bind (Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse). The second messengers activated on the ileum by 5-HT is dependent on the receptors activated as listed above – excluding 5-HT3, which has a direct