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It happens slowly to many years, and in stages. There are five stages of kidney disease. At each stage, the kidneys do not function as well as stage by. From the diagnosis of CRF and comments on the abnormal results obtained on a plasma sample collected from a 75year old female. She has chronic renal failure (CRF). The importance process of CRF determined by glomerular filtration rate. Glomerular filtration. So that the Clinical Biochemist can identify abnormalities of electrolytes, urea and Creatinine. Estimate the glomerular filtration rate ( eGFR) teste measure the level of creatinine in the blood. The medical care of patients is Delaying or halting the progression of CRF, Diagnosing and treating the pathologic manifestations of CRF and timely planning for long-term renal replacement therapy. The diagnosis is chronic renal failure and stage for this patient is stage 3. Chronic renal failure is a critical period in the development of chronic renal disease and is associated with complications and associated diseases. Monitoring should be regularly for eGFR. They should management of chronic renal failure and improve patient outcomes. I recommended further investigation is necessary to define these biomarkers in terms of usefulness in assessing renal function. The impact and Complications from chronic kidney disease progress to kidney