IBM involves both muscle fibre degeneration and chronic inflammation but is primarily a degenerative disorder rather than an inflammatory muscle disease. Inclusion body myositis is associated with a modest degree of creatine kinase (CK) elevation and an abnormal …show more content…
The Involvement of the tibialis anterior muscle leads to ankle dorsiflexion weakness. Dysphagia affects up to 70% of patients and can be a significant problem. Mild to moderate facial weakness is frequently demonstrated (Dimachkie, M. M., & Barohn, R. J. 2012, July). Due to severe quadriceps weakness and atrophy patellar reflexes may be lost. Progression of leg weakness results in falls ultimately leading to wheelchair confinement in 10 to 15 years from onset. In my friend Ted’s case due to stronger muscles before the onset of IBM helped in delaying the inevitable use of wheelchair. Ted only uses wheelchair for longer distances. Though IBM is felt to be a neurodegenerative disorder, there is some association with autoimmune disorders. Systemic lupus erythematosus, Sjögren’s syndrome, thrombocytopenia, and sarcoidosis have been reported in up to 15% with IBM. There is no increased risk of myocarditis, interstitial lung disease, or malignancy in IBM (Amato, A. A., & Barohn, R. J.