Nipah Virus can replicate very easily in human lung fibroblasts. It can infect the surrounding cells by either cell-to-cell spread or through release of infectious particles. When monocytes get infected, they can transmigrate through the blood brain barrier to infect the brain. This could be plausible if the monocytes were inefficient in early clearance of the virus. Nipah virus can also infect neuronal cells but cannot spread viral infection (13).
Pathogenicity:
In humans, Nipah virus colonizes mainly in nasopharyngeal and tracheal secretions during its early stages of infections which in later stages …show more content…
(24).
III. Francisella tularensis
Francisella tularensis is a fastidious (requires cystiene), aerobic, gram-negative, coccobacilli, non-sporulating, non-motile bacteria (25, 26). Francisella tularensis causes Tularemia. It is spread by bites from insects like deerflies, ticks. Also, it could get transmitted via infected animals like rabbits, rodents, hares, reptiles, birds, fish ,etc. It could also be airborne via inhalation of aerosols emerged from infected animals (27).
Common symptoms could be swelling and pain in lymph glands, fever, chills, headache, fatigue, ulcers in case of insect bites. It can follow many routes for entry like, ulceroglandular, glandular, oculoglandular, oropharyngeal, pneumonic, typhoidal and septic. Different routes can result