Antibiotic resistance occurs when microbe evolves and become more resistant to antibiotics drug and it can lead to the treatment of many bacterial infections becoming increasingly limited, expensive and ineffective (Harbarth, Albrich & Brun-Buisson, 2002). The number multi-drug resistant TB infection is as high as 480,000 each year, and the fight against antibiotic-resistant HIV and malaria is spreading around the world. According to the Centers for Disease Control and Prevention (CDC), in United States there are as many as two million people developing an infection caused by antibiotic-resistant bacteria every year and 23,000 die as a direct result of these antibiotic-resistant infections annually (Kotwani et al., 2016).
In addition, antibiotic resistance also imposes a significant financial burden on economies. As the antibiotic-resistant infections require longer and more …show more content…
However, the only passive education such as lectures, educational events, leaflets and handouts without restrictive or supportive interventions, has been proved less effective in changing antimicrobial prescribing behaviors and has little long-term impact. Besides, education with only printed educational materials also have had little effect on reduce the prescribing for antibiotics or other medications in the outpatient setting (Pulcini & Gyssens, 2013). Combine the education program with restrictive programs such as feedback or the development of practice guidelines can be more effective (Lee et al.,