induces circadian clock and behavioral cycle misalignment in order to evaluate metabolic, autonomic, and endocrine function. The study population consisted of 10 adult subjects, 5 of which are female. A comprehensive medical examination was conducted prior to the study to ensure the subjects were healthy with no significant medical conditions. The investigators first established a stable baseline of circadian phase angle entrainment by having subjects “maintain a regular sleep-wake schedule for 2 weeks” (6). Once a stable circadian phase angle of entrainment was established, subjects were placed in a laboratory suite that excluded environmental time cues. During 10-day laboratory protocol, the first two day and nights were used to establish a baseline with 8 hours of sleep. Following the baseline days, subjects experienced 7 recurring 28 hour sleep-wake
induces circadian clock and behavioral cycle misalignment in order to evaluate metabolic, autonomic, and endocrine function. The study population consisted of 10 adult subjects, 5 of which are female. A comprehensive medical examination was conducted prior to the study to ensure the subjects were healthy with no significant medical conditions. The investigators first established a stable baseline of circadian phase angle entrainment by having subjects “maintain a regular sleep-wake schedule for 2 weeks” (6). Once a stable circadian phase angle of entrainment was established, subjects were placed in a laboratory suite that excluded environmental time cues. During 10-day laboratory protocol, the first two day and nights were used to establish a baseline with 8 hours of sleep. Following the baseline days, subjects experienced 7 recurring 28 hour sleep-wake