The process of complete regeneration of damaged tissues or cells usually referred as the wound healing. Generally, normal wound healing was a tedious and systemic process. Moreover sometimes if the wound was deep into the skin then that wound will be prone to microbial growth and sepsis hence in order to prevent it several therapies were in use. Even though there were many therapies for wound healing such as sutures, ligatures etc, all of them had been failed in promoting faster regeneration of the tissues. This had been a major problem for the wound healing concept.
Hydrogels are basically polymeric networks because of the hydrophilic nature they were capable of swelling in water and also exhibits excellent biocompatibility with the skin tissues. In case of hydrogels amount of water content was always more than the amount of polymer content. Due to their large water content, they usually exhibit the degree of flexibility similar to that of natural tissue hence due to this reason these hydrogels were known to have various applications. In case of wound healing, this hydrogels plays an important role in the delivery of multiple growth factors. Selection of polymers usually plays …show more content…
In this study, PVA was selected based on advantages of its density, rheological swelling elasticity and adhesive properties which were observed in previous documents, However, profile of PVA the swelling hydrogels depends on the amount of time that it was immersed in water. Apart from above characteristics this polymer also exhibits good water solubility, biocompatibility, drug compatibility, film forming, and mechanical properties. As the drug release was slowed down at higher concentration because of that reason low molecular weight of hydrogel was preferred in this present