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What is sperm-zona binding?
Sperm cell membrane has a receptor for ZP3 (located on the zona pellucida), and this is species-specific.
* This triggers the acrosome reaction
What is acrosome reaction?
The outer part of the acrosome membrane fuses with the sperm cell membrane. The acrosome releases the enzymes to penetrate the zona pellucida.
What is sperm-egg binding?
The sperm cell membrane has a ligand that binds to the receptor on the secondary oocyte membrane. This is NOT species-specific.
What are the acrosomal enzymes?
Hyaluronidase & acrosin accelerates the zona penetration
What happens to the sperm after the sperm-egg binding?
The sperm cell membrane and organelles enter the secondary oocyte but they are degenerated.
What is ZP3 made up of?
gluco-protein
What is the postacrosomal segment?
The part of the sperm cells that has sperm cell membrane. This part attaches to the oocyte membrane since the outer part of the sperm cell membrane has been lost during acrosome reaction.
- This is not species-specific
When is the meiosis II completed?
When the sperm binds to the egg; this triggers the meiosis II completion.
What happens when the sperm binds to the oocyte membrane?
- the oocyte completes the meiosis II
- the oocyte membrane release cortical granules, which triggers the zona reaction.
What is zona reaction?
Zona reaction: cortical granules damages the ZP3 so that is it no longer recognizable by the sperm cells & ** the zona becomes rigid; the sperm cells cannot enter anymore (block to polyspermy)
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