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4 Cards in this Set
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eicosanoids are derived from what? how is it released?
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arachidonic acid. histamine stimulate a2 or phospholipase c to release esterified arachidonic acid from plasma membrane
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what is dietary precursor for arachidonic acid?
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linoleate - c 9, 12.
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there are 3 pathways for arachidonic acid metabolism. name them.
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1. cyclo-oxygenase - prostaglandin and thromboxane synthesis
2. lipoxygenase - leukotrienes, hetes, lipoxins 3. cytochrome p450 - epoxides, hetes, dihetees |
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Chronic NSAID use causes?
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cut out cycloxygenase pathway (aspirin) and over production of lipoxygenase.
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