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4 Cards in this Set
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What drug is the best for CML?
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imatinib (gleevac) 400mg/day
raise dose to 600-800mg/day with GCSF if excessive myelosupression for resistance or intolerance try dasatinib, or nilotinib |
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what if none of the tyrosine kinase inhibitors work?
what does the CML have that inhibits these? |
T-315 I mechanism of resistance
try a clinical trial or HCST i availible last ditch use interferon |
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what is an alternative, older treatment?
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interferon alpha (+/-) cytarabine
if this works proceed to HSCT if available |
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What should be done if there is an acute blast crisis?
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increase imatinib to 600-800 mg/day, try dasatinib or nilotinib, or treat as either ALL or AML (whichever it resembles)
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