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20 Cards in this Set
- Front
- Back
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Binds to 30S ribo sub of bacteria
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Aminoglycosides
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Animo group, form zwitterions at body pH to pass
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Aminopenicillin (B-Lac)
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Carboxlyic acid
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B-Lactam
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Carbon with B-lac
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Carbapenems
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Large ring, B-lac
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Cephalosphorins
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Binds to 50s ribo sub of bacteria, substrate of CYP 3A4 (cytochrome P450), Highly lipophilic
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Chloramphenicol
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Fluordidation inhibits DNA gyrase and topoisomerase
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Fluoroquiolones
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Prevent cross-linking of cell wall polymers
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Glycopeptide
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Binds to 23s ribo sub (part of 50S) of bacteria
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Ketolide
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Binds to 50s ribo sub of bacteria, substrate of CYP 3A4 (cytochrome P450)
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Lincosamides
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Inhibits bacterial RNA polymerase
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Macrocyclic Antibotic
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Binds to 50s ribo sub of bacteria, substrate of CYP 3A4 (cytochrome P450)
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Macrolide
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Binds to 50S and 30S ribo sub of bacteria
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Oxazolidinone
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Big ring sturcture to protect B-lac
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Penicillinase-Resistant Penicillins
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Targets bacterial DNA-dependent RNA polymerase
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Rifamycins
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Binds to 50s ribo sub of bacteria, substrate of CYP 3A4 (cytochrome P450)
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Strepogramins
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Folate antagonist, inhibit PABA synthesis to Folic acid
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Sulfonamides
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Binds to 30S ribo sub of bacteria
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Tetracyclines
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Folate antagonist, inhibit PABA synthesis to Folic acid
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Trimethoprim
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Liberates formaldehyde in acid
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Urinary antiseptic
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