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21 Cards in this Set
- Front
- Back
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what percentage of the circulating blood volume is stored in the veins?
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60%
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what are the 3 major groups of predisposing factors of thrombosis (Virchow's triad)?
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1) stasis and other disturbances in blood flow
2) abnormalities in the vessel wall 3) changes in blood composition tending to increase its coaguability |
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which substances when released by platelets will stimulate further platelet aggregation?
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ADP and thromboxane A2
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what feature of aggregated platelets promotes coagulation?
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activated phosolipid complex
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What is factor V leiden?
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factor V has mutated to be resistant to protein C
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which deficiency has the highest relative risk of venous thromboembolism?
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antithrombin III deficiency (RR 50)
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what is the relative risk of venous thromboembolism associated with the OCP?
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3.8
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what is the RR of VTE associated with factor V leiden?
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5-8
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what does the lupus anticoagulant antibody bind to?
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beta2 glycoprotein 1
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which malaria is associated with cerebral malaria?
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falciparum
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how many layers of RBCs are in a thick film?
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20-30
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what are the characteristic thin film findings for P, falciparum?
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samll ring forms (may be more than 1 per RBC), more than 1 chromatid dot, 5-10% RBCs parasitised
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what is warfarin?
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competitive Vit K antagonist
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how is warfarin therapy monitored?
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INR
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what is the desirable INR for warfarin therapy for VTE?
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2-3
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how is warfarin reversed?
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oral or IV vit K, prothrombin complexes, FFP
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t/f... heparin has good oral bioavailability
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false, heparin is only active parenterally
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what are the advantages of LMWH over conventional heparin?
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more predictable anticoag response, longer half-life, fewer side effects
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what reverses heparin?
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protamine
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how is heparin monitored?
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activated partial thromboplastin time (1.5 to 2.5 times the normal range)
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name two drugs which directly inhibit thrombin
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lepirudin, argatroban
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