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24 Cards in this Set

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  • Back
Nephritic Syndrome
Acute Inflammation, Glomerular BM injury

Type III Hypersensitivity

RBC casts, decreased urine, swelling face
These Have RBC/casts in urine
- Nephritic Syndrome
○ Acute Glomerulonephritis
- IgA Nephropathy
- Acute Pyelonephritis
- Renal Cell Carcinoma
- Papillary Transition Cell Carcinoma
NephrOtic Synedrome
ChrOnic injury to glomerulus

High serum lipids, lipiduria, Edema,
Chromic Renal Failure
Loss of renal function

Anemia, bleeding, infections, Uremic Frost

Pericarditis
Glomerulonephritis General Features
Mesangial cell proliferation & Thickening of BM
Acute Glomerulonephritis
Strep infection

Aggregates Ag-Ab complexes, Fix Complement --> Flaming inflammatory rxn

Nephritic (RBC casts )

Mesaginal cells, Irregular granular pattern
Membranous Glomerulonephritis
Slow Ag-Ab complexes Chronic Hep B

Lots of protein loss

Nephrotic Syndrome

BM damage, diffuse pattern, linear, smooth contours
Goodpasture's Syndrome
Pulmonary viral infection --> Ab against pulmonary & Glomerular BM

Type II Hypersensitivity
Membranoproliferative Glomerulonephritis
Hybrid appearance

Type 1: immune complex
Type 2: Ab stabilizes protein --> no brakes on Alt Pathway activation (Dense Body Disease)

Some proliferation & membranous thickening

Split BM, train track
Minimal Change Glomerulonephritis
Children 2-6

Foot Processes Dz damage, no Neg charge, Edema

Loose lots of Protein

Nephrotic Syndrome


Tx: glucocorticoids
Diabetic Nephropathy
Kimmelstiel-Wilson

thickens BM everywhere--> Ischemic Injury
Leading cause of Renal Failure
DM
IgA Nephropathy
Mid 20'sulates in mesangium


IgA Accum

many episodes Hematuria/ Acute nephritis
Acute Tubular Necrosis
Drink Anti-Freeze, Ischemic (complicating factor of something else)

Tubular cells die --> clog tubule

no urine, loose Concentration gradient --> 6L/day
Pyelonephritis
Pyelo = Connective Tissue

Kidney Interstitial Inflammation

Acute (Bacterial) & Chronic
Acute Pyelonephritis
Kidney Interstitial Inflammation

Bacterial (G neg rods)

Blood/Pus/Casts in urine
3 Key features of Chronic Inflammation
Ongoing tissue destruction

round cells (Lymphocytes)

Fibrosis
Chronic Pyelonephritis
kidney connective tissue

Vascular Dz association

Vascular Insufficiency --> Chronic Ischemia

--> scarring & Chronic inflammation
Thyroidization

Papillary Necrosis
HTN & Kidney
Vascular damage = thichened vessel walls

low blood flow --> release Renin

Chromic Pyelonephritis, Renal Failure, Thyroidization
Cystic Disease
Transmembrane protein mutation --> cells keep growing

compresses kidney tissues

Tubular Epithelium
Renal Cell Carcinoma
Metastatic - from tubular epithelium

Makes Erythropoitin

painless Hematuria
Wilm's Tumor
Children Mom says something wrong

Embryonic never became Kidney
Kidney stones
Hydroephrotic kidney
Papillary Transition Cell Carcinoma
Lower urinary tract epithelium