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24 Cards in this Set
- Front
- Back
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Nephritic Syndrome
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Acute Inflammation, Glomerular BM injury
Type III Hypersensitivity RBC casts, decreased urine, swelling face |
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These Have RBC/casts in urine
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- Nephritic Syndrome
○ Acute Glomerulonephritis - IgA Nephropathy - Acute Pyelonephritis - Renal Cell Carcinoma - Papillary Transition Cell Carcinoma |
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NephrOtic Synedrome
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ChrOnic injury to glomerulus
High serum lipids, lipiduria, Edema, |
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Chromic Renal Failure
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Loss of renal function
Anemia, bleeding, infections, Uremic Frost Pericarditis |
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Glomerulonephritis General Features
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Mesangial cell proliferation & Thickening of BM
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Acute Glomerulonephritis
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Strep infection
Aggregates Ag-Ab complexes, Fix Complement --> Flaming inflammatory rxn Nephritic (RBC casts ) Mesaginal cells, Irregular granular pattern |
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Membranous Glomerulonephritis
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Slow Ag-Ab complexes Chronic Hep B
Lots of protein loss Nephrotic Syndrome BM damage, diffuse pattern, linear, smooth contours |
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Goodpasture's Syndrome
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Pulmonary viral infection --> Ab against pulmonary & Glomerular BM
Type II Hypersensitivity |
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Membranoproliferative Glomerulonephritis
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Hybrid appearance
Type 1: immune complex Type 2: Ab stabilizes protein --> no brakes on Alt Pathway activation (Dense Body Disease) Some proliferation & membranous thickening Split BM, train track |
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Minimal Change Glomerulonephritis
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Children 2-6
Foot Processes Dz damage, no Neg charge, Edema Loose lots of Protein Nephrotic Syndrome Tx: glucocorticoids |
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Diabetic Nephropathy
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Kimmelstiel-Wilson
thickens BM everywhere--> Ischemic Injury |
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Leading cause of Renal Failure
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DM
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IgA Nephropathy
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Mid 20'sulates in mesangium
IgA Accum many episodes Hematuria/ Acute nephritis |
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Acute Tubular Necrosis
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Drink Anti-Freeze, Ischemic (complicating factor of something else)
Tubular cells die --> clog tubule no urine, loose Concentration gradient --> 6L/day |
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Pyelonephritis
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Pyelo = Connective Tissue
Kidney Interstitial Inflammation Acute (Bacterial) & Chronic |
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Acute Pyelonephritis
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Kidney Interstitial Inflammation
Bacterial (G neg rods) Blood/Pus/Casts in urine |
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3 Key features of Chronic Inflammation
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Ongoing tissue destruction
round cells (Lymphocytes) Fibrosis |
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Chronic Pyelonephritis
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kidney connective tissue
Vascular Dz association Vascular Insufficiency --> Chronic Ischemia --> scarring & Chronic inflammation Thyroidization Papillary Necrosis |
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HTN & Kidney
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Vascular damage = thichened vessel walls
low blood flow --> release Renin Chromic Pyelonephritis, Renal Failure, Thyroidization |
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Cystic Disease
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Transmembrane protein mutation --> cells keep growing
compresses kidney tissues Tubular Epithelium |
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Renal Cell Carcinoma
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Metastatic - from tubular epithelium
Makes Erythropoitin painless Hematuria |
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Wilm's Tumor
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Children Mom says something wrong
Embryonic never became Kidney |
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Kidney stones
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Hydroephrotic kidney
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Papillary Transition Cell Carcinoma
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Lower urinary tract epithelium
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