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11 Cards in this Set
- Front
- Back
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Is there a genetic factor in MS?
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Yes. (30% of monozygotic twins, 3% dizygotic)
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Where is the MS susceptibility associated with HLA?
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Class II region of the MHC
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How is EBV implicated in MS?
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-99% in MS (90% in controls)
-Late EBV infection particularly -EBV resembles some myelin proteins |
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What is the proposed pathogenesis of MS?
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-Thelper 1 cells recognise components of the mywlin sheath
-Activated, autoreactive T cells within lesions drive chronic inflammation and activate macrophages that destroy myelin |
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Can remyelination occur in MS?
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Yes.
-May be spontaneous from surviving oligodendrocytes -New oligodendrocytes may proliferate from progenitor cells |
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How are corticosteroid used to treat MS?
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Transiently restore blood-brain barrier
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In treating MS, how are inflammatory cells prevented from vascular adhesion and migration with the antibody?
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With natalizumab: alpha4-integrin antagonist
*alpha4-integrin is expressed in the surface of T cells and it mediates the adhesion with the endothelium |
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How are T cells addressed in the treatment of MS?
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-Deplete circulating T cells
-Block TCR/antigen/MHC class II interraction (glatiramer) -Vaccinate against T cells |
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How is interferon beta used in the treatment of MS?
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-Reduces MHC II expression
-Reduces proliferation of T cells -Reduces TNF production |
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How can plasma exchange be used in the treatment of MS?
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The antibodies are removed
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Where is aqueous humour drained?
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Through the canal of Schlemm. Some also passes via an alternate outflow through uveoscleral tissues
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