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29 Cards in this Set
- Front
- Back
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The choice of antineoplastic therapy is dependent on what?
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diagnosis, site involvement, stage, patient
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What should you as a dentist perform before the patient starts antineoplastic therapy?
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Perform a baseline oral examination
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Before patient receives antineoplastic therapy, you should perform any procedures necessary to eliminate sources of ___________ infection.
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Odontogenic infection
also perform a prophy |
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What supplementation is essential for patients who receive radiation therapy to head an neck?
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Fluoride
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Surgical procedures should be performed at least _______ before chemotherapy. Before radiation therapy?
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1 week before chemo
3 weeks before radiation |
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Does mucositis occur in CT or RT?
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BOTH
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What is one of the first symptoms of antineoplastic therapy to resolve? and in how long?
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Mucositis
Resolves in 2-3 wks after treatment |
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Hemorrhage is a complication of which antineoplastic therapy?
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Chemotherapy (CT)
hepatic damage --> clotting factors decrease |
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What is a clinical feature of hemorrhage due to chemotherapy?
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Petechiae
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What complication of antineoplastic therapy is characteristic of erythema, edema, erosions, ulcerations?
What type of therapy is this from? |
Dermatitis due to Radiation Therapy
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Which gland is the most radiosensitive?
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Parotid
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What type of therapy is associated with osteoradionecrosis?
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Radiation therapy (RT)
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Osteoradionecrosis occurs more often in the maxilla or mandible?
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mandible
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_________ is the best form of treatment for Osteoradionecrosis.
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PREVENTION
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What is the name for loss of taste, and what therapy is it associated with?
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Hypogeusia
RT |
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Trismus is associated with which therapy?
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RT
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Neuropathic pain and neurotoxicity is associated with what therapy?
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Chemotherapy
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What is the most common fungal infection during Antineoplastic therapy?
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candidiasis
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Viral infections associated with which therapy?
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CT
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There is a lifelong risk of what 2 complications from radiation therapy?
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osteoradionecrosis and xerostomia
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What are the 2 sources of stem cells in bone marrow transplantation?
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Autologous bone marrow (patients own stem cells removed and reinfused)
Allogeneic bone marrow (marrow from healthy donor) |
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What are the 5 phases of the bone marrow transplant process?
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Conditioning
Stem cell processing and infusion Neutropenic phase (decrease in WBC) Engraftment phase (WBC rebounds) Post-engraftment stage (tolerance) |
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Graft-versus-hot disease (GVHD) occurs most often in which type of BMT?
What is the main factor that causes this? |
Allogeneic BMT
Histocompatibility match |
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2 stages of GVHD?
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Acute -first few weeks of BMT
Chronic - >100 days after BMT |
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What are the effects of Biphosphonates?
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Reduction of bone turnover.
Inhibition of osteoclast activity increased osteoclast apoptosis Osteoclast dysfunction |
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How does the ADA define osteonecrosis of the jaws (ONJ)?
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Oral mucosal ulceration, EXPOSURE OF UNDERLYING BONE
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85% of cases of osteonecrosis of the jaws have a history of _________ or ________.
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multiple myeloma or breast cancer
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___% of ONJ cases are associated with IV biphosphonate therapy
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94
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What are the 3 main preventative measures to help prevent osteonecrosis of the jaws?
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Eliminate all foci of oral infection
Restore/optimize oral health Avoid dentoalveolar trauma |
