- Shuffle
Toggle OnToggle Off
- Alphabetize
Toggle OnToggle Off
- Front First
Toggle OnToggle Off
- Both Sides
Toggle OnToggle Off
Front
How to study your flashcards.
Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key
Up/Down arrow keys: Flip the card between the front and back.down keyup key
H key: Show hint (3rd side).h key
PLAY BUTTON
PLAY BUTTON
15 Cards in this Set
- Front
- Back
|
Metabolic disorder marked by increased amounts of uric acid in the blood
|
GOUT
|
|
These three things can exacerbate acute attacks of GOUT
|
high alcohol consumption
high purine diet kidney disease |
|
Chronic gout may be due to what two things?
|
kidney disease or malignancy
|
|
What is the DOC for acute gout attacks?
|
Colchicine
|
|
Colchicine is CI in what patient population and should be used with caution in what two other situations?
|
CI in pregnancy and with caution in hepatic and CV disease
|
|
MOA of Allopurinol
|
(-) xanthine oxidase
|
|
HGPRT deficiency results in an accumulation of what?
|
hypoxanthine and guanine
|
|
What is the "uricosuric agent" that may be used to treat chronic gout
|
probenecid
|
|
chronic gout may be seen in this XLR disorder affecting primarily males that results in self mutilation
|
Lesch-Nyhan Syndrome
|
|
What enzyme is deficient in Lesch Nyhan syndrome?
|
HGPRT - hypoxanthine-guanine phosphoribosyl transferase
|
|
How does cancer treatment result in gout?
|
overabundance of nucleic acid from dying malignant cells
|
|
Which NSAID is CI in gout treatment?
|
ASPIRIN
|
|
Why is aspirin CI in gout?
|
it competes with uric acid at the renal transporters in the PCT
|
|
Some
Pharmaceuticals Plus Urate Stop Transporters |
Sulfonamides
Probenecid Penicillins Uric Acid Salicylates Thiazides |
|
How does EXCESS uric acid result in gout?
|
phagocytosed by neutrophils which release leukotrienes and other mediators of inflam; the lysosomes are ruprutred and the phagocyte dies causing enzymes and the urate to be released causing acute inflammation
|
