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15 Cards in this Set

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What two cell types are present within synovium?
Type A: responsible for phagocytosis
Type B: produces synovial fluid
Does synovium have a basement membrane?
No: facilitates fluid transport
What three components of plasma are absent in synovial fluid?
Red blood cells
Hemoglobin
Clotting factors
Compare complement levels in synovial fluid with rheumatoid arthritis and ankylosing spondylitis.
Rheumatoid arthritis: decreased levels of complement
Ankylosing spondylitis: normal levels of complement
How does the viscosity of synovial fluid change with shear? What does that say about synovial fluid?
Viscosity increases as shear decreases
So synovial fluid is non-newtonian
Under conditions of high strain, what two things happen to the hyaluronan within synovial fluid?
Becomes entangled and forms a relatively solid cushion
Relative proteoglycan concentration increases
Under conditions of instability, what happens to the hyaluronan within synovial fluid?
Hyaluronan content and efficacy decrease
Under conditions of disuse, what happens to the hyaluronan within synovial fluid?
No change
What are the two key lubricating components of synovial fluid?
Lubricin: a glycoprotein
Superficial zone protein (SZP)
What is hydrodynamic lubrication?
A thin film completely separates two articulating surfaces
What is elastic lubrication?
Articular surfaces deform slightly when loaded to create pockets of fluid
What is the primary method by which normal articular cartilage is lubricated?
Elastohydrodynamic: a combination of elastic and hydrodynamic lubrication
Comparison/review: What is the primary lubrication method for hard-on-soft articular bearings?
Boundary method
Some points of contact between surfaces but separation adequate to minimize wear
Comparison/review: What is the primaiy lubrication method for hard-on-hard articular bearings?
Mixed: hydrodynamic and boundary methods
What does "weeping" refer to?
Under conditions of loading, fluid shifts to loaded areas of articular cartilage