Adrenergic Antagonists

alpha-antagonist
-relatively selective
-primarily metabolized
-half life 2-3 hrs, dosing 2-3 times/day

predictable S/E: orthostatic hypotension (first pass effect), reflex tachycardia, nasal congestion, inhibition of ejaculation

specific alpha antagonist
-longer half life (22hrs--single daily dosing)

predictable S/E:orthostatic hypotension, reflex tachycardia, nasal congestion, inhibition of ejaculation

specific alpha-antagonist
-long half life (12 hrs--single daily dosing)

predictable s/e: orthostatic hypotension, reflex tachycardia, nasal congestion, inhibition of ejaculation
-unique s/e: headache

specific alpha-antagonist
-indicated only for BPH
-shorter half life requires tid dosing

S/E similar to prazosin +HA
-food decreases both rate and extent of oral absorption

specific alpha-antagonist
-indicated only for BPH
-formulated as extended release tablets resulting in half life of 10 hrs=single daily dosing
-well tolerated

specific alpha-antagonist
-very new
-indicated only for BPH
-long half life = single daily dosing
-may be less likely to reduce BP
-metabolized extensively by CYP3A4, so anticipate drug interactions with agents dependent on this isoenzyme for metabolism
-fairly well tolerated

beta-adrenergic blocking agent
-nonselective: blocks beta 1 and beta 2

beta-adrenergic blocking agent
-cardioselective: blocks only beta 1 receptors
-selectivity lost at high doeses

unique beta-blockers
-non-selective
-has alpha 1 blocking effects (lowers bp)
-one of two agents indicated for CHF
-alpha 1 blocking activity wears off after a few weeks

unique beta-blocker
-non selective
-has alpha 1 blocking effects (lowers bp)
-much more unique
-alpha 1 blocking activity persists
-used for hypertension due to this combined effect, although, it's no more effective than other beta-blocking drugs that don't have alpha 1 blocking

newest beta-blocker
-oral only
-primarily selective beta 1 blocker
-can cause beta 2 blockatde
-also has nitric oxide releasing properties--facilitates vasodilation
-approved for use to treat hypertension

ADRs: common- HA, fatigue, dizziness. less common-all ADRs of others