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20 Cards in this Set
- Front
- Back
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MOA furosemide in treating acute hypercalcemia?
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inhibits Ca reabsorption in the loop of henle to increase Ca excretion
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What diuretic will treat Ca containing kidney stones?
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thiazide diuretic
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MOA of sodium phosphate in treating hypercalcemia?
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complexes with free, ionized calcium to reduce plasma ionized calcium levels
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What effect does PTH have on bone?
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takes Ca and P out of bone
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MOA pamidronate in treating hypercalcemia?
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concentrates in bone and inhibits osteoclast-induced bone resorption to decrease Ca release from bone and reduce plasma Ca levels
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What drug can cause osteonecrosis of the jaw and bone or muscle pain?
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bisphosphonates
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MOA calcitonin in treating hypercalcemia?
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hormone that decreases bone resorption and increase Ca excretion by the kidney
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MOA cinacalcet in treating hypercalcemia?
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Sensitizes the Ca sensing receptor on parathyroid cells to inhibit PTH secretion at lower levels of serum Ca than normal.
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Which can cause hypocalcemia? Calcitriol, cinacalcet, vitamin D, Bisphosphonates
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cinacalcet
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What are the 3 main drugs to treat osteoporosis?
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Bisphosphonates
Calcitonin Teriparatide |
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What is the MOA of teriparatide in treating osteoporosis?
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recombinant PTH analogue - when given once a day in the fall (exogenous, intermittent stimulation), it actives the PTH receptor on osteoblasts to increase their activity and deposit bone.
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What are the 2 main treatments of Paget’s disease
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Calcitonin
Bisphosphonates |
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What is the difference between cholecalciferol or vitamin D, calcitriol and paricalcitol?
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What is the difference between cholecalciferol or vitamin D, calcitriol and paricalcitol?
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What happens to PTH levels with Rickets?
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increased
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Which agent works better in a patient with Rickets?
Vitamin D or Calcitriol |
both about the same
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Which agent works better in a patient with hypoparathyroidism?
Vitamin D or Calcitriol |
calcitriol
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Which agent works better in a patient with chronic renal disease?
Vitamin D or Calcitriol |
calcitriol
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What happens to PTH levels with chronic renal disease?
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increased
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What is the MOA of paricalcitol in treating chronic kidney disease?
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decrease PTH secretion which will prevent bone resorption (use when calcitriol causes unacceptably high serum Ca levels)
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What is the MOA of cinacalcet in treating chronic kidney disease?
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sensitizes the Ca sensing receptor on the parathyroid gland to Ca which decreases PTH hormone release thereby preventing bone resorption
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