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6 Cards in this Set
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Androgens
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Testosterone
Testosterone esters 17-alpha-alkylated androgens |
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Drugs to block Androgen Activity
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Receptor Inhibitors
5-alpha reductase inhibitor |
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Gonadotropin-related drugs
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GnRH agonists
GnRH antagonists |
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Testosterone
Testosterone esters 17-alpha-alkylated androgens |
Uses: Hypogonadism of hypothalamic/pituitary origin and gonadal failure or insufficiency
Dosage: begin slowly and gradually increase; establish lifetime maintenance Problems: can not be given orally (except 17-alpha-alkylated androgens, but HEPATOTOXIC) - better given transdermally |
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Receptor Inhibitors (Flutamide)
5-α Reductase inhibitor (Finasteride) |
Helps block formation of androgen that supports prostate growth and hyperplasia (BPH)
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GnRH agonist (leuprolide)
GnRH antagonist |
Chemical castration
Agonist - given chronically will desensitizes receptors so won't produce more hormones Given with androgen receptor antagonist to prevent disease flare at initiation of agonist, and blocks effects of adrenal androgens |
