- Shuffle
Toggle OnToggle Off
- Alphabetize
Toggle OnToggle Off
- Front First
Toggle OnToggle Off
- Both Sides
Toggle OnToggle Off
Front
How to study your flashcards.
Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key
Up/Down arrow keys: Flip the card between the front and back.down keyup key
H key: Show hint (3rd side).h key
PLAY BUTTON
PLAY BUTTON
9 Cards in this Set
- Front
- Back
|
Two major mechanisms for preventing Nucleic acid synthesis in microbes?
|
1) Inhibition of folic acid synthesis (without Folic acid, there will no Uracil conversion to Thymine, and no/reduced formation of Adenine and Guanine = decreased DNA/RNA production)
2) Inhibition of topoisomerase II and IV. |
|
This group of drugs are involved in inhibiting Topoisomerase II and IV.
|
Fluoroquinolones
|
|
List the fluoroquinolones (6)
Name the one quinolone. |
Fluoroquinolones:
1) Norfloxacin 2) Levofloxacin 3) Ciprofloxacin 4) Ofloxacin 5) Gemifloxacin 6) Moxifloxacin Quinolone: Naldixic acid |
|
These enzymes are targets for inhibition when your goal is to inhibit nucleic acid synthesis in microbes.
|
Dihydropterate synthetase
Dihydrofollate reductase |
|
MOA of Sulfonamides?
|
Competitively inhibit Dihydropterate synthetase.
|
|
Enzyme found in bacteria but not humans, that allows for the formation of folic acid.
|
Dihydropterate synthetase
|
|
MOA of Trimethoprim?
|
Inhibits dihydrofollate reductase.
|
|
MOA of Pyrimethamine?
|
Inhibition of dihydrofollate reductase.
|
|
Name the two common combination therapies used in nucleic acid synthesis inhibition.
|
1) Trimethoprim-Sulfamethoxazole
2) Pyrimethamine-Sulfadiazine |
