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28 Cards in this Set
- Front
- Back
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What are the major drug categories that work on the 30s subunit to inhibit protein synthesis?
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1) Aminoglycosides
2) Tetracyclines 3) Glycylcyclines |
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What are the major drug categories that work on the 50s subunit to inhibit protein synthesis?
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1) Macrolides
2) Other (Chloramphenical and Clindamycin) 3) Newer antimicrobials (Linezolid, Quinupristin/Dalfopristin) |
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What group of anti-bacterial protein synthesis inhibitors is both bacteriostatic AND bacteriocidal?
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Aminoglycosides
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During which event of protein synthesis do Aminoglycosides work?
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Initiation/Formation of initiation complex.
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During which event of protein synthesis does Linezolid work?
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Initiation/Formation of initiation complex.
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Where do Aminoglycosides bind?
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30s subunit
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Where does Linezolid bind?
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50s subunit
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What is the MOA of aminioglycosides?
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1) Interfere with initiation codon functions - block association of 50s ribosomal subunit with mRNA-30s (bacteriostatic)
2) Incorporation of wrong amino acids (bacteriocidal) |
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What is the MOA of linezolid?
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1) Interfere with initiation codon functions - block association of 50s ribosomal subunit with mRNA-30s (bacteriostatic)
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During which event do Tetracyclines work?
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Amino-acid incorporation
(1st step of Elongation) |
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During which event do Quinupristin/Dalfopristin work?
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Translocation
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What is the binding site of Tetracyclines?
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30s subunit
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What is the binding site of Quinupristin/Dalfopristin?
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50s subunit
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What is the MOA of tetracyclines?
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Block the attachment of aminoacyl tRNA to acceptor site, or "A" site (bacteriostatic)
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What is the MOA of Dalfopristin/Quinupristin?
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Inhibits translocation of peptidyl-tRNA from acceptor site (A site) to P site. (bacteriorstatic)
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During which event does chlroamphenicol work?
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Formation of Peptide bond
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During which event do macrolides work?
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Translocation
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During which event does clindamycin work?
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Translocation
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Where does chloramphenicol bind?
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50s subunit
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Where do macrolides bind?
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50s subunit
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Where does clindamycin bind?
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50s subunit
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What is the MOA of chloramphenicol?
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Inhibits the activity of peptidyltransferase (bacteriostatic)
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What is the MOA of macrolides?
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Inhibits translocation of peptidyl-tRNA from acceptor site (A site) to P site. (bacteriorstatic)
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What is the MOA of clindamycin?
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Inhibits translocation of peptidyl-tRNA from acceptor site (A site) to P site. (bacteriorstatic)
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Name the aminoglycoside(s).
Also, name the aminoglycoside relative (1). |
Streptomycin
Gentamycin Amikacin Tobramycin Neomycin+Kanamycin Spectinomycin |
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Name the tetracycline(s).
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Doxycycline
Minocycline Demeclocycline |
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Name the glycylcycline(s).
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Tigecycline
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Name the macrolide(s).
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Erythromycin
Azithromycin Clarithromycin |
