- Shuffle
Toggle OnToggle Off
- Alphabetize
Toggle OnToggle Off
- Front First
Toggle OnToggle Off
- Both Sides
Toggle OnToggle Off
Front
How to study your flashcards.
Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key
Up/Down arrow keys: Flip the card between the front and back.down keyup key
H key: Show hint (3rd side).h key
PLAY BUTTON
PLAY BUTTON
15 Cards in this Set
- Front
- Back
|
sulfonamides inhibit:
this enzyme is active in humans/bacteria? |
dihydropteroate synthetase. (comp inhib, mimics PABA)
active in bacteria only |
|
sulfonamide - uptake:
|
oral.
sulfasalazine - not absorbed. given orally to cure ulcerative colitis. |
|
trimethoprim inhibit:
this enzyme is active in humans/bacteria? |
dihyrdofolate reductase
active in bacteria and humans, yet drug has much higher affinity for bacterial form |
|
anti-folate cocktail
|
TMP-SMZ. trimethoprim-sulfamethoxazole. aka Bactrim
|
|
bactrim uses - long list - TMP-Smz mnemonic
|
Tree - resp tree. strep pneu and h influ
Mouth - GI tract: shigella, salmonella, e coli, vibrio cholerae - though quinolone are 1st choice Pee - UTI's from e coli Smz - aidSYNDROME - pneumocystis pneumonia not any anaerobes |
|
bactrim main use:
|
UTIs
|
|
fluoroquinolone - mechanism:
|
interfere with topoisomerase / gyrase
|
|
fluroquinolone mnemonic:
|
all have -floxacin suffix. think of "flock of sinners" who "gyrate their hips as they party and dance" as they inhibit DNA gyrase
|
|
fluroquinolone uptake:
inhibitors of uptake: |
absorbed orally.
inhibited by cations that are present in antacids, e.g. Al and Mg |
|
fluoroquinolone elimination:
|
mostly kidney. some of them are liver, or a combination of kidney/liver.
|
|
fluoroquinolone uses:
|
-crotch area: gonorrhea, UTI, prostatitis, PID
-pneumococcal pneumonia, pseudomonas -GI - 1st choice for shigella, salmonella, e coli, cholera, campylobacter |
|
fluoroquinolone side effects:
|
N/D/V
cartilage damage - especially kids QT interval prolongation tendinitis |
|
Metronidazole: trade name and reason
|
Flagyl - kills flagellated bugs
|
|
metronidazole uses:
|
anaerobics - C Diff
anaerobic protozoa - trichomonas, giardia, entamoeba |
|
metronidazole: why won't it work against aerobes?
|
drug must be reduced to be activated. aerobes have too low redox potential.
|
