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6 Cards in this Set
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Heparin
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Activates antithrombin III, decreases thrombin & factor Xa.
Intrinsic pathway inhibitor, increases PTT more than PT. Short half-life. Does not cross placenta. Antidote = protamine sulfate |
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Warfarin
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Inhibits synthesis & gamma-carboxylation of vit K dependent factors (II, VII, IX, X, prot C, prot S).
Crosses placenta (teratogen). Inhibits extrinsic pathway, increases PT. Antidote = vitamin K, fresh frozen plasma |
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Aspirin
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Irreversibly inhibits COX-1 and COX-2.
Increased bleeding time. No change to PT, PTT. SE: ulcers, bleeding, hyperventilation, Reye's syndrome, tinnitus (CN8) |
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Clopidogrel, Ticlopidine
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Inhibits platelet aggregation. Irreversibly blocks ADP receptors, blocks GP IIb/IIIa expression.
SE: ticlopidine = neutropenia |
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Abciximab
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Inhibits platelet aggregation, antibody to GP IIb/IIIa receptors.
SE: thrombocytopenia |
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tPA, urokinase, streptokinase, anistreplase
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Thrombolytics, aid conversion of plasminogen to plasmin and cleaves thrombin/fibrin clots.
Antidote = aminocaproic acid (fibrinolysis inhibitor) |
