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24 Cards in this Set
- Front
- Back
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acetaminophen
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N-acetylcysteine (regenerates glutathione, which is needed to conjugate NAPQI)
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salicylates
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NaHCO3 (alkalinize urine), dialysis
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amphetamines
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NH4Cl (acidify urine)
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anticholinesterases, organophosphates
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atropine + pralidoxime
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Antimuscarinic, anticholinergic agents
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physostigmine salicylate
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beta blockers
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glucagon
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digitalis
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stop digitalis, normalize potassium, give lidocaine, give magnesium, give anti-dig Fab
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iron
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deferoxamine (binds free iron in blood, enhances its excretion in urine)
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lead
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dimercaprol, succimer, CaEDTA, penicillamine
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mercury, arsenic, gold
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dimercaprol, succimer
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copper, arsenic, gold
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penicillamine
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cyanide
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nitrite, hydroxocobalamin, thiosulfate
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methemoglobin
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methylene blue, vit C
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carbon monoxide
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100% O2, hyperbaric O2
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methanol, ethylene glycol (antifreeze)
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ethanol, dialysis, fomepizole (competitive inhibitor alcohol dehydrogenase)
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opioids
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nalaxome, naltrexone
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benzodiazepines
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flumazenil (competitive inhib of benzo binding site on GABAa-R
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TCA's
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NaHCO3 (serum alkalinization)
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Heparin
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protamine sulfate
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warfarin
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vit K, FFP
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tPA, streptokinase
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aminocaproic acid
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theophylline
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beta blocker
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LEAD POISONING
(Mechanism, Symptoms, Dx, Treatment, Risk factors) |
Mechanism: lead denatures ferrocheletase (so iron can't bind w/ protoporphyrin to form heme); also inhibits ALA dehydrase. also denatures ribonuclease, so it can't break down RNA --> basophilic stippling!
SYMPTOMS: lead lines (Burton's lines) on gingivae and epiphyses of long bones on xray, encephalopathy, abdominal cholic, wrist (radial palsy), foot drop (perineal palsy). DX: blood lead level, also if did bone marrow bx, would see sideroblasts. TREATMENT: dimercaprol and EDTA. Succimer for kids. RISK FACTORS: chipped pain houses, auto factory, pottery painter, moonshine. |
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IRON POISONING
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cell death due to peroxidation of membranes.
acute: gastric bleeding chronic: metabolic acidosis, scarring --> GI obstruction. TREATMENT: deferoxamine |
