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152 Cards in this Set
- Front
- Back
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DOC late east African sleeping sickness
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Melarsoprol
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DOC late west African sleeping sickness
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Eflornithine
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MOA Melarsoprol
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Reacts w/ sulfhydryl grps = non-functional enzymes
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MOA Eflornithine
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Inhibits ornithine decarboxylase
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SE melarsoprol
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Hypersens
GI Fatal neurotox |
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SE Eflornithine
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Thrombocytopenia
Seizures |
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DOC Amoebiasis
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Metronidazole
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MOA Metronidazole
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DNA & protein destructive agent
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SE Metronidazole
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Disulfram-like rxn if taken w/ EtOH
Dark urine |
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DOC Anaerobic infections above diaphragm
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Clindamycin
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MOA Clindamycin
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Protein synthesis inhibitor
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SE Clindamycin
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Strong a/w C.diff growth
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DOC Anaerobic infection below diaphragm
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Metronidazole
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DOC ankylosing spondylitis
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Indomethacin
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MOA Indomethacin
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Inhibits COX --> prevents PG synthesis
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SE Indomethacin
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GI upset & bleed
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DOC Anthrax
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Penicillin
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MOA Penicillin
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Cell wall synthesis inhibitor
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DOC Anxiety d/o
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SSRI or TCA daily
AND BDZ PRN |
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MOA TCAs
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Block reuptake NE, serotonin
Block mescarinic, alpha, H1 R |
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MOA BDZ
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enhance GABA binding to GABA R --> Cl entry
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SE SSRI
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Loss of libido
Wt gain Seizure w/ OD |
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SE TCAs
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Dry mouth
Constipation Urinary retention Wt gain |
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DOC Aspergillosis
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Voriconazole
(Amp B) |
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MOA Voriconazole
SE |
Ergosterol synthesis inhibitor
Skin rxn Hepatotox Visual changes Photosens |
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DOC autoimmune d/o
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Steroids
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DOC B. cereus
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Vanco or Clindamycin
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MOA Vanco
SE |
Cell wall & membrane synthesis inhibitor
Red man syndrome |
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DOC Bacterial vaginosis
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Metronidazole
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DOC BPH
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5-alpha reductase inhibitor (finasteride, dutasteride, turosteride)
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MOA 5-alpha reductase inhibitor
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Inhibit the enzyme responsible for conversation of Testosterone to dihydrotestosterone
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SE 5-alpha reductase inhibitors
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Erectile dysfunction
Decreased libido Decreased ejaculatory volume |
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DOC Bipolar
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Lithium
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MOA lithium
SE |
Interferes w/ Na movement and exchange
Ataxia DI Seizures |
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DOC Blastomycosis
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Itraconazole
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MOA Itraconazole
SE |
Ergosterol synthesis inhibitor
Hepatotox |
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DOC Campylobacter jejuni
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Erythromycin
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MOA Erythromycin
SE |
Protein synthesis inhibitor
QT prolongation |
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DOC Candidiasis, systemic
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Fluconazole
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MOA Fluconazole
SE |
Ergosterol synthesis inhibitor
Hepatotox |
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DOC Chagas disease (early)
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Nifurtimox
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MOA Nifurtimox
SE |
Destroys enzymes --> creation of ROS
Abd pain/N/V Exacerbates G6PD deficiency |
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DOC Chlamydia trachomatis
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Doxycycline
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MOA Doxy
SE |
Protein synthesis inhibitor
Stain children's teeth Photosensitivity Pseudotumor cerebri |
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DOC Cholecystitis
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Piperacillin & tazobactam
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MOA Piperacillin
SE |
Cell wall synthesis inhibitor
Hypersens. |
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MOA Tazobactam
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Beta-lactamase inhibitor
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DOC CMV Retinitis
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Ganciclovir & Valganciclovir
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MOA ganciclovir
SE |
DNA synthesis inhibitor
BM suppression |
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DOC CHF
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Digoxin
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MOA Digoxin
SE |
Inhibits Na/K pump --> increase in Ca entry
Visual changes Arrhythmias |
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DOC Conjunctivitis (non-GC, non-Chlam)
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FQ
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MOA FQ
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Topoisomerase inhibitors
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DOC Cryptococcal meningitis
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Amp B & Flucytosine
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MOA Amp B & Flucytosine
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Amp B: Ergosterol antagonist & cell membrane pore former
F: DNA synthesis inhibitor |
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SE Amp B & Flucytosine
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Amp B: Nephrotox, ototox
F: BM tox |
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DOC DM type 2
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Metformin
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MOA Metformin
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Inhibits absorption of glucose from bowel
Decreases GNG Increases glucose uptake in fat & sk m. |
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SE Metformin
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Adverse rxn only w/ IV administration
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DOC Diarrhea, severe
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Cipro or levo & metronidazole
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MOA cipro
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Topoisomerase inhibitor
Cartilage damage in kids Tendon rupture in elderly Photosens CNS tox |
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DOC Diptheria
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Erythromycin
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MOA Erythromycin
SE |
Protein synthesis inhibitor
QT prolongation |
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DOC Diverticulitis
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Metronidazole & Cipro
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DOC DVT
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Heparin
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MOA Heparin
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Activates antithrombin III
(inhibits factors 2, 9, 10, 11, 12) |
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DOC Encephalitis
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Acyclovir
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MOA Acyclovir
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Viral DNA synthesis inhibitor
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DOC Enterobius vermicularis
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Mebendazole
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MOA Mebendazole
SE |
Prevents microtubule formation = no glucose uptake
Albend - teratogenic, hepatotox, BM tox Mebend - teratogenic |
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DOC Erectile dysfunction
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PDE-5 inhibitors
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MOA PDE-5 inhibitors
SE |
Decreases the degradation of cGMP
Priapism Blindness Deafness |
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DOC Fungal infections, dermatiaceous (black mold)
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Itraconazole
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DOC Fusarium spp
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Amp B
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DOC Genital herpes
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Acyclovir
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DOC Giardiasis
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Tinidazole
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MOA tinidazole
SE |
DNA & protein destructive agent
Disulfiram rxn |
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DOC Gonorrhea
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Ceftriaxone
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MOA Ceftriaxone
SE |
Cell wall synthesis inhibitor
Hypersens |
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DOC Gout
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Colchicine
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MOA Colchicine
SE |
Binds tubulin
(prevents WBC migration, proliferation & release of inflammatory agents) Teratogenic |
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DOC H. influenzae
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Cefotaxime OR Ceftriaxone
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DOC Herpes keratitis
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Trifluridine eye drops
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MOA trifluridine eye drops
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DNA synthesis inhibitor
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DOC Histoplasmosis
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Itraconazole
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DOC HIV
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2 NRTIs + (1 NNRTI or 1 PT or 1 INTI or 1 CCRA)
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MOA NRTIs
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Prevents DNA manufacture from viral RNA by acting as nucleoside analog
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MOA NNRTIs
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Prevents DNA manufacture from viral RNA by inhibiting reverse transcriptase
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MOA PIs
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Prevents cleavage & activation of major viral proteins
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MOA INTI
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Inhibits viral integrase preventing integration & insertion of HIV DNA into human DNA
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MOA CCRA (CCR5 blocker)
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Prevents viral binding to cells (CD4 T-cells)
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DOC Hypercholesterolemia
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HMG CoA Reductase inhibitor
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SE statins
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Hepatotox
Myopathy --> Rhabdo |
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MOA HTN
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Thiazides
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SE Thiazides
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Hypokalemia
Hypercalcemia Hyperuricemia Sulfa-allergy |
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DOC Hyperthyroidism
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Radioablation w/ Na iodine
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DOC Hypothyroidism
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Levothyroxine
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DOC Influenza
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Oseltamivir or Zanamivir
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MOA oseltamivir or zanamivir
SE |
neuraminidase inhibitor
Z - Bronchospasm |
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DOC Listeriosis
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Ampicillin
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DOC Lyme dz
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Doxycycline
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DOC MDD
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SSRI
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DOC Measles
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Kid - Vit A
Adult - Ribavirin (viral transcription inhibitor) |
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DOC Meningitis
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(Ceftriaxone or Cefotaxime) & Dexamethasone & Vanco
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DOC prophylaxis of close contacts for Meningitis
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Rifampin
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MOA Rifampin
SE |
RNA synthesis inhibitor
Hepatotox BM suppression |
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DOC Meningococcal meningitis
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Pen G
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DOC MI, acute
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ASA
Heparin B-blocker Nitro Morphine O2 |
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DOC mild diarrhea
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Loperamide
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MOA Loperamide
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Decreases peristalsis d/t binding to opioid R
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DOC MRSA
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Vanco
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DOC Myasthenia gravis
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Physostigmine or Neostigmine
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MOA physostigmine
SE |
Cholinesterase inhibitor
Increase bladder & GI motility |
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DOC Mycoplasma pneumonia
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Azithromycin
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DOC Neuropathic pain
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Gabapentin
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DOC Osteomyelitis
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Nafcillin or Oxacillin
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DOC Osteoporosis
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Bisphosphonates
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SE Bisphosphonates
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Heartburn
N Erosive gastritis Jaw osteonecrosis |
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DOC otitis externa
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Ofloxacin drops or
(polymyxin & neomycin & hydrocortisone) or (cipro & hydrocortisone) |
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DOC PD
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Dopaminergic agents
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SE dopaminergic agents
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Impulse control d/o
Sleep attacks Hallucinations |
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DOC PE
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Heparin
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DOC Peptic ulcer
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Omeprazole
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DOC Pneumocystis jiroveci (carinii)
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TMP-SMX
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MOA TMP-SMX
SE |
Folate synthesis/utilization inhibitor
Megaloblastic anemia |
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DOC Pneumonia
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Ceftriaxone & azithromycin
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DOC Prostatits < 35 yo
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Ceftriaxone followed by doxy
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DOC Prostitis > 35 yo
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FQ or TMP-SMX
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DOC Pseudomembranous colitis
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Metronidazole
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DOC Scedosporium apiospermum
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Voriconazole
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DOC Scedosporium proliferans
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Itraconazole
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DOC Seizure absence
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Ethosuximide
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SE Ethosuximide
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Nephrotox
Hepatotox Grand mal seizure |
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DOC seizure febrile (ongoing)
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Phenobarbital
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MOA phenobarbital
SE |
Increases GABA effect
Decreased cognitive performance Resp. depression |
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DOC seizure generalized
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Phenytoin
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MOA phenytoin
SE |
Blocks Na and Ca entry
CNS depression - ataxia Gingival hyperplasia Megaloblastic anemia SIADH Hyperglycemia Hirsutism Teratogenic |
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DOC seizure partial
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Carbamazepine
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MOA Carbamazepine
SE |
Na channel blocker
BM suppression Skin rxn Cardiac Hepatotox Hypothyroidism |
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DOC shigellosis
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Azithro or FQ
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DOc Sporotrichosis
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Itraconazole
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DOC status epilepticus
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Diazepam
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DOC Strep pneumonia
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Pen G
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DOC Strep pyogenes
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Pen G
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DOC Syphilis
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Pen G
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DOC Thrush
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Fluconazole
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DOC Trichinosis
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Albendazole & Prednisone
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DOC Trichomoniasis
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Metronidazole
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DOC Trigeminal neuralgia
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Carbamazepine
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DOC UTI, inpt
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Cipro or Levo
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DOC UTI, outpt
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TMP-SMX
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DOC vaginal candidiasis
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Miconazole
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