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33 Cards in this Set
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Atg1
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Serine-theronine protein kinase which forms a complex with Atg 13 to assist in retrieval of Atg9 from the PAS (together with Atg 2 and Atg18).
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Atg2
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Peripheral membrane protein which together with Atg18 and the Atg1 complex is required for Atg9 retrieval from the PAS.
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Atg3
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Ubiquitin-like E2 conjugating enzyme for Atg8 in the Ubl-protein system
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Atg4
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Cysteine protease which processes the C terminus of Atg8 to expose the glycine residue and release PE.
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Atg5
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Protein forming complex with Atg12 and Atg 16. Atg5 is required for membrane association during autophagosome formation.
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Atg6
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Part of the PI(3)K complex (Vps30) - Mammalian homologue = beclin-1
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Atg7
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E2-like activating enzyme in the Ubl protein system.
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Atg8
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Ubl protein attaches to phosphatidylethanolamine (PE) released by Atg4 and recruited to nasent autophagasomes
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Atg9
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Cycles between PAS and cytosol necessary for phagophore formation. (Transport factors include Atg23 and Atg27).
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Atg10
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Ubiquitin-like E2 conjugating enzyme for Atg12 in the Ubl-protein system
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Atg11
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need to complete
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Atg12
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Ubl protein which modifies Atg5 to form a multimeric complex with Atg16 - required for autophagosome formation
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Atg13
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Regulatory subunit of the Atg1 complex (Vps15). Functions with Atg17.
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Atg14
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Part of the PI(3)K complex in yeast - no mammalian homolgue characterized
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Atg15
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Protein kinase required for Vps34 activation
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Atg16
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Protein which forms complex with Atg12 and Atg5. Atg16 self interaction required for oligomerazation of the complex during autophagosome formation.
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Atg17
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Regulatory scaffold subunit of the Atg1 complex. Functions with Atg13.
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Atg18
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Peripheral membrane protein which together with Atg2 and the Atg1 complex is required for Atg9 retrieval from the PAS.
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Atg19
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Specific to Saccharomyces cerevisiae. A cargo receptor for the cargo-to-vacuole targeting (Cvt) pathway.
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Atg20
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need to complete
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Atg21
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need to complete
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Atg22
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need to complete
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Atg23
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Soluble protein which together with Atg27 assists in the shuttling of Atg9 to the PAS.
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Atg24
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need to complete
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Atg25
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need to complete
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Atg26
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need to complete
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Atg27
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Type I transmembrane protein which together with Atg23 assists in the shuttling of Atg 9 to the PAS.
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Atg28
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need to complete
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Atg29
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need to complete
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Atg30
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need to complete
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Vps34
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Class III PI(3)K
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UVRAG
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Activating protein of the beclin-1 PI(3)KCK complex promoting autophagy. Mutations associated with colon cancer.
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bif-1
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Part of the beclin-1, PI(3)KCK complex promoting autophagy.
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