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3 Cards in this Set
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Mutations increasing translation accuracy
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Mutations in ribosomal proteins S12, S17, L6, or in 23S RNA at position G2583 or in the 2660 loop increase accuracy
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Mutations decreasing translation accuracy
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Mutations in ribosomal proteins S4, S5, L7/L12, EF-Tu, Release factors 1 and 2, in 16S RNA at positions 530, 960, 1400, 1490 or in 23S RNA at position 2555 decrease the accuracy of protein synthesis
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Three groups of structural elements of the ribosome influence the fidelity of protein synthesis
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1. regions of 16S RNA and proteins of the small ribosomal subunit that form the decoding region, involved in sensing the structure of the codon–anticodon complex and in creating the conformational signal of codon recognition ( [Ramakrishnan, 2002] and [Ogle et al., 2003])
2. parts of rRNA at the subunit interface that mediate transmission of the conformational signal to the 50S subunit 3. regions of the 50S subunit that receive and convert the signal by accelerating EF-Tu GTPase activation and aa-tRNA accommodation ( [Saarma and Remme, 1992] and [Rodnina and Wintermeyer, 2001]) |
