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59 Cards in this Set

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What is the Veterinarian's role?
Provide the regimen:
- Route of administration
- Dosage
- Frequency
- Duration
- "Please give Fluffy Amoxicillin by mouth 50 mg twice daily for 10 days."
What is the Technician's role?
-Administer the correct drug at the correct time with the correct route.
-Observe the animal's response.
-Question the vet if unsure.
-Create and affix labels.
-Explain instructions to the client.
-Record information in medical records.
What are "The Five Rights"?
Right Patient
Right Drug - Check Label
Right Dose
Right Route
Right Time and Frequency
What is Pharmacokinetics?
Primary factors that influence blood concentration levels of a drug and a patient's response?
- Rate of Absorption
- Amount of drug absorbed
- Distribution of drug thoughout the body
- Drug Biotransformation
- Rate and route of excretion
What are the Routes of Administration?
Oral
Parenteral
Inhalation
Topical
How does the Oral administration provide treatment?
By mouth, not absorbed quickly. Influenced by pH of drug, solubility, size and shape of molecule, presence of food in the GI tract, diseases (vomiting).

Lasts longer than injections.
Takes longest to work but has longest duration.
How does the Parental administration provide treatment?
Given by injection.
IV, IM, SC (or SQ), ID, IP, IA, intraarticular(joint), Intracardiac, intramedullary(bone marrow), epidural/subdural(spinal cord)
Onset of action IV>IM>SC
Duration of action SC>IM>IV
IV route most toxic
How does the Inhalation administration provide treatment?
Anesthetics
brochodilators
How does the Topical administration provide treatment?
Placed on skin or mucous membranes. Examples are Frontline. Kills fleas, flea eggs and ticks.
What is Bioavailability?
Mechanism of absorption
pH and ionization of the drug
Absorptive surface area
Blood supply to the area
Solubility of the drug
Dosage
Status of GI tract
Other medications
What are the methods of drug absorption?
Active, Passive, Pinocytosis.
What is Passive Absorption?
Similar to putting something in water and it naturally disperses. Or same for air.
How does the Drug Distribution work?
Site of absorption
plasma of bloodstream
intersitial fluid surrounding cells
into cell
What is Biotransformation?
Metabolism
Affected by: Species, Age, Nutritional Status, Tissue Storage, Health Status
How do drugs generally move through the system?
Most drugs are metabolized by the LIVEr and then eliminated by the KIDNEYS via urine.
What is pharmacodynamics?
Lock and key model
Agonist
Antagonist
No drug produces a single effect
balance - therapeutic indiex
half life
efficacy
adverse drug reaction - report to FDA
What about Drug Names?
Chemical (...)
Code or laboratory (C1-581)
Compendial (ketamine)
Official (ketamine)
Proprietary or trade (Ketaset, Vetalar)
Generic (ketamine)
Explain the Drug Label!
Drug names (generic and trade)
Drug concentration and quantity
Name and address of manufacturer
Controlled substance status
Manufacturer's control or lot number
Expiration date
Insert: instructions for drug use and warnings of possible adverse effects.
An undesirable response to a drug by a patient. It may vary in severity from mild to fatal.
Adverse Drug Reaction
A drug that brings about a specific action by binding with the appropriate receptor.
Agonist
A drug that inhibits a specific action by binding with a particular receptor.
Antagonist
Any manipulation (e.g., diluting, combining) performed to produce a dosage-form drug, other than the manipulations described in the directions for use on the labeling of an approved drug product.
Compounding
A substance used to diagnose, prevent, or treat disease.
Drug
The extent to which a drug causes the intended effects in a patient.
Efficacy
The use of a drug that is not specifically listed on the US Food and Drug Admins approved label.
Extralabel Use
The amount of time (usually expressed in hours) that it takes for the quantity of a drug in the body to be reduced by 50%.
Half-Life
The bulk production of drugs for resale outside of the veterinarian-cleint-patient relationship.
Manufacturing
The biochemical process that alters a drug from an active form to a form that is inactive or that can be eliminated from the body.
Metabolism (Biotransformation)
Another word for Metabolism?
Biotransformation
The route of administration of injectable drugs.
Parenteral
The ratio of the solubility of substances (e.g., gas anesthetics) between two states in which they may be found (e.g., blood and gas, gas and rubber goods).
Partition Coefficient
A drug that is limited to use under the supervision of a veterinarian because of potential danger, difficulty of administration, or other considerations. The legend that designates a prescription drug states the following: (Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian."
Prescription (Legend) Drug
A program for administration of a drug that inclueds the route, the dose (how much), the frequency (how often), and the duration (for how long) of administration.
Regimen
An amount of a drug still present in animal tissue or products (e.g., meat, milk, eggs) at a particular point (slaughter or collection).
Residue
The set of circumstances that must exist between the veterinarian, the client, and the patient before the dispensing of prescription drugs is appropriate.
Veterinarian-Client-Patient Relationship
The length of time it takes for a drug to be eliminated from animal tissue or products after it is no longer used.
Withdrawal Time
What is the complex sequence of events that occurs after a drug is administered to a patient?
Pharmacokinetics
IV stands for?
Intravenous
IM stands for?
Intramuscular
SC stands for?
Subcutaneous
ID stands for?
Intradermal
IP stands for?
Intraperitoneal
IA stands for?
Intraarterial
What is the study of the mechanisms by which drugs produce physiologic changes in the body.
Pharmacodynamics
A drug with a high level of affinity and efficacy causes a specific action and is an?
agonist
A drug with limited affinity and efficacy is a partial...?
agonist.
A drug that blocks another drug from combining with a receptor is an?
antagonist.
The Center for Veterinary Medicine of the FDA requires that drug container labels must list the following items?
Drug Names (both generic and trade names)
Drug concentration and quantity
Name and address of the manufacturer
Controlled substance status
Manufacturer's control or lot number
Drug's expiration date
What book lists all animal drug products that have been approved by the FDA for safety and effectiveness?
The Green Book
A waxy secretion of the glands of the external ear canal.
Cerumen
An agent that produces superficial irritation that is intended to relieve some other irritation.
Counterirritant
A semisolid preparation of oil, water, and a medicinal agent.
Cream
A hydroalcoholic liquid that contains sweeteners, flavoring, and a medicinal agent.
Elixir
A medicinal agent that consists of oily substances dispersed in an aqueous medium with an additive to stabilize the dispersion.
Emulsion
A medicine in an oily, soapy, or alcoholic vehicle to be rubbed on the skin to relieve pain or to act as a counterirritant.
Liniment
A semisold preparation that contains medicinal agents for application to the skin or eyes.
Ointment
Administration by a route other than the alimentary canal (e.g., intramuscular, subcutneous, intravenous).
Parenteral
An instrument for dilating a body orifice or cavity to allow visual inspection.
Speculum
A preparation of solid particles idspersed in a liquid but not dissolved in it.
Suspension