BBC Pharmacology Chapters 1-3 Flash Cards

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Title:	BBC Pharmacology Chapters 1-3
Description:	Assignment 4
Number of Cards:	52
Save Count:	1
Author:	bkelly15
Created:	2012-01-17
Tags:	bbc pharm
Private	No

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- Question
- Answer
- Side 3

- Sulfonamides
- antibiotics
  easily displaced from albumin
  inhibit p450
  compete at renal transporters
- Phenylbutazone
- analgesic
  used for arthritis and gout
  easily displaced from albumin
  inhibits p450
- Tolbutamide
- hypoglycemic agent
  used for type II diabetes mellitus
  easily displaced from albumin
- Coumadin, dicumarol
- anticoagulant
  easily displaced from albumin
  inhibits p450
- Alcohol
- induces p450
- Barbiturates
- sedative and anti-spasmodic
  induces p450
- Phenytoin
- antileptic; used for epilepsy and other seizure disorders
  induces p450
- Rifampin
- antibiotic (transcription inhibitor)
  induces p450
- Chloramphenicol
- antibiotic, protein syn inhibitor
  inhibits p450
- Probenecid
- uricosuric agent at high doses
  competes at renal transporters
- Penicillin
- antibiotic
  competes at renal transporters
- salicylates
- analgesic
  competes at renal transporters
- thiazides
- diuretic
  competes at renal transporters
- methadone
- analgesic and treatment of heroin addiction
  induces p450
- Levodopa L-dopa
- stimulates dopamine production, used in parkinsons
  induces p450
- OCP
- oral contras
  induce p450
- isoniazid
- antibacterial used for TB
  inhibits p450
- cimetidine
- H2 blocker
  inhibits p450
- drugs easily displaced from albumin
- Serum proteins can spew
  
  sulfonamides
  phenylbutazone
  coumadin
  sulfonylureas
- drugs that induce p450
- One pharm brings about rapid liver metabolism
  
  OCP
  phenytoin
  barbiturates
  alcohol
  rifampin
  levodopa
  methadone
- drugs that inhibit p450
- Some pharm classes inhibit drug catabolism
  
  sulfonamides
  phenylbutazone
  chloramphenicol
  isoniazid
  dicumarol
  cimetidine
- drugs that compete for renal transporters
- some pharmaceuticals plus urate stop transporters
  
  sulfonamide
  probenecid
  penicillin
  urate
  salicylates
  thiazides
- MAO with SSRIs or TCAs may promote
- serotonin syndrome
  
  (with TCAs severe sympathetic activation)
- aminoglycosides
- antibiotic; inhibit protein synthesis in gram negatives aerobic
- MAO inhibitors
- monoamine oxidase inhibitors
  antidepressants: work by increasing monoamines (epi norepi)
- TCAs
- inhibit reputake or nepi and serotonin
- SSRIs
- inhibit reuptake of serotonin
- fluroquinolones
- inhibit topoisomerase, antiobiotic
- halothane
- anesthetic
  may cause malignant hyperthermia
- phenacetin
- analgesic
  nephrotoxicity
- interferon
- may used to treat chronic hep b or c or MS
  
  hepatotoxic
- NSAIDS
- nephrotoxic with chronic use
  teratogenic
- alpha-blockers
- anti HTN
  orthostatic hypotension
- meperidine
- opiod analgesic
  
  can cause serotonin syndrome with MAOi
  can cause seizures
- bupropion
- antipdepressant and smoking cessation
  
  SE: lowers threshold to seizure activity
- cyclosporine
- immunosuppresive used for prophylax with oragn transplant
  
  nephrotoxic
- procainamide
- SVT and ventricular arrythmias
  
  drug-induced lupus
- tamoxifen
- an estrogen receptor modulator used for treatment of breast cancer
- raloxifene
- estrogen receptor modulator used for osteoporosis
- hydralazine
- vascular smooth muscle relaxant and artery dilator
  
  drug induced lupus
- niacin
- vitamin b3
  used for pellagra
  
  niacin flush
- primaquine
- antimalarial
  
  may cause G6PD exacerbation
- foscarnet
- used for CMV retinitis
- cidofovir
- used for CMV retinitis
  DOC for smallpox/severe adenovirus
  
  nephrotoxic
- ganciclovir
- antiviral usually for CMV
  
  bone marrow toxic
- Imidazole
- anti-fungal...most common
  
  hepatotoxic
- nevirapine
- non nuke..HIV
  
  hepatoxic
- HMG coA reductase inhibitor
- statins
  high cholesterol
  
  hepatoxic
- valproic acid
- anti-seizure medication, mood stabilizer
  
  hepatoxic, can cause neural tube defects
- zidovudine
- anti-HIV
  
  bone marrow toxic
- 5 alpha reductase inhibitors
- tx for BPH
  
  decreased libido and ED
- PDE-5 inhibitors
- tx for ED
  
  rare SE include blind, hearing loss