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26 Cards in this Set
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- Back
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50-60 years old
Dilated ducts Palpable periareolar mass Chronic inflammation |
Duct ectasia
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Cyclic/non cyclic pain
Discrete/full mass Gallactorrhea Blood unilateral discharge is possible |
Fat necrosis
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What is present in women less than 35 y.o.?
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fibroadenoma, mastitis, fat necrosis, cancer
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What is different about women 35-50 y.o.?
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fibrocystic changes are at the top of the list, carcinoma is second, papilloma is a possibility (last one)
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What is different about women more than 50 y.o.?
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carcinoma is first on the list, fibrocystic changes are second, Paget's disease becomes an option (in the middle), and papilloma is still last on the list.
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20-40 years old
Cyst formation (with fluid, calcifications, and apocrine metaplasia) Benign Adenosis (number of ducts per lobule increase) Non- proliferative |
Fibrocystic changes
On histo--Huge hole on the left with a smaller one on the right side. |
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What do the two histo slides look like for FCC?
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Many small clumped circles that are gray on the left side.
Many magenta bigger clumps that are on the right side. |
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A proliferative lesion--double the amount of acini
Fibrosis and glandular crowding Mimicks cancer, but is benign Prominent myoepithelial cells |
Sclerosing adenosis
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Mimicks cancer, both radiologically and grossly.
Radiating bands of fibrosis Benign |
Radial scar
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Benign and no atypia
What does it look like on histo? |
florid ductal hyperplasia
Histo--An angled oval on the left side, that is a purple color. |
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What is important about Atypical Ductal Hyperplasia?
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The nuclei are becoming atypical and there is an increased risk of cancer now.
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What does a duct carcinoma in situ look like on histo?
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A squash on the bottom with a circle to its right. On the left there is a small star.
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What does a benign duct cyst look like on histo?
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Like bubbles. They are small on the left and progressively get larger.
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During the reproductive years
Stromal and glandular hyperplasia Firm, rubbery, mobile Benign Changes with menstrual cycle, and gets smaller and disappears with menopause |
Fibroadenoma
On histo--slits and loose fibrous stoma No proliferation of atypia |
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Proliferates and is larger than fibroadenomas
Can be malignant--more cellular with increased mitosis Hematogenous metasasis |
phyllodes tumor
On histo--very cellular on the left and ductal n the right. |
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Solitary lesion usually at the ducts near the nipple
Sometimes with a bloody discharge Benign The MC type of disease with bloody discharge |
Intraductal papilloma
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Histo with strands of stroma in the left and right upper corners and the middle of the bottom side
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Sclerosing adenosis
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Histo with a duct FILLED with epithelial proliferation with slits on the periphery.
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Epithelial hyperplasia
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What are features of BRCA 1 mutation?
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poorly differentiated, medullary, ER and PR negative, and HER2/Neu negative, younger ages, and a higher ovarian cancer risk.
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On histo, what does LCIS look like?
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a bunch of grapes in a well-circumscribed sphere
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What does invasive ductal carcinoma look like of histo?
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Light blue stoma with clusters of brown circular cells.
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What does invasive lobular carcinoma look like on histo?
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cancer cells in a single file or a bunch of thin circular layers.
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Large
Rapid growth, but takes long to metastasize. Less desmoplasia Frequent mitosis Most are triple negative Good prognosis--70% 5year survival |
Medullary carcinoma
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What does colloid (mucinous) carcinoma look like on histo?
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Clear mucin in between S-shaped purple cells.
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Intra-epithelial carcinoma of the skin
Eczema involving the nipple |
Paget's disease with "halo cells"
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Small, well formed tubules
ER positive, HER2/Neu negative Rarely metastasizes 40 y.o. "A good cancer to have" |
Tubular carcinoma
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