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2 Cards in this Set
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What changes occur within a platelet when it is activated? What differences can be observed in its morphology following activation?
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Activated platelets swell and take on an irregular form, extending pseudopodia (as shown in b). Granules become more prominent and there is also cytoskeletal contraction, which results in the release of the granule contents. Activated platelets can express more GPIIb/IIIa receptors and become more “sticky” so that they adhere to ECM proteins & they aggregate with other platelets (fibrinogen linker). Activated platelets also secrete bioactive factors involved in the coagulation cascade.
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An experimental cardiovascular biomaterial with a positive surface charge was implanted in an animal model. Histological analysis of the harvested implants revealed that coagulation occurred shortly after implantation. (a) Which of the two pathways of the coagulation cascade is most likely responsible for this result? (b) How would the coagulation time differ between this and the remaining pathway?
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(a) Extrinsic, (b) Extrinsic: 15 seconds, Intrinsic: 1-6 minutes.
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