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49 Cards in this Set

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homeostais
the process by which the body's substances and characteristics, such as temperature and glucose level are maintained at their optimal level
ingestive behavior
eating or drinking
system variable
a variable that is controlled by a regulatory mechanism; for example, temperature in a heating system
set point
the optimal value of the system variable in a regulatory mechanism
detector
in a regulatory process, a mechanism that signals when the system variable deviates from its set point
correctional mechanism
in a regulatory process, the mechanism that is capable of changing the value of the system variable
negative feedback
a process whereby the effect produced by an action serves to diminsih or terminate that action; a characteristic of regulatory systems
satiety mechansim
a brain mechanism that causes cessation of hunger or thirst, produced by adequate an available supplies of nutrients or water
extracellular fluid
all body fluids outside cells, intersitial fluid, blood plasma, and cerebrospinal fluid.
intersitial fluid
the fluid that bathes the cells, filling the space between the cells, the interstices
isotonic
equal in osmotic pressure to the contents of a cell. A cell placed in an isotonic solution neither gains nor loses water
hypertonic
the characteristic of a solution that contains enough solute that it will draw water out of a cell placed in it, through the process of osmosis
hypotonic
the characteristic of a solution that contains so little solute that a cell placed in it will absorb water, through the process of osmosis
hypovolemia
reduction in the volume of the intravascular fluid
osmometic thirst
thirst produced by an increase in the osmotic pressure of the interstitial fluid relative to the intercellular fluid, thus producing cellular dehydration
osmoreceptor
a neuron that detects changes in the solute concentration of the interstitital fluid that surrounds it
volumetric thirst
thirst produced by hypovolemia
renin
a hormone secreted by the kidneys that causes the conversion of angiotensinogen in the blood into angiotensin
angiotensin
a peptide hormone that constricts blood vessels, causes the retention of sodium and water, and produces thirst and a salt appetite
subfornical organ (SFO)
a small organ located in the confluence of the lateral ventriles, attached to the underside of the fornix; contains neurons that detect the presence of angiotensin in the blood and excite neural circuits that initiate drinking
median preoptic nucleus
a small nucleus stiuated around the front of the anterior commissure; plays a role in thrist stimulated by angiotensin
glycogen
a polysacchride often referred to as animal strach; stored in lever and muscle; constitutes the short-term store of nutrients
insulin
a pancreatic hormone that facilitates entry of glucose and amino acids into the cell, conversion of glucose not glycogen, and transport fats into adipose tissue
glucagon
a pancreatic hormone that promotes the conversion of liver glycogen into glucose
triglyceride
the form of fat storage in adipose cells; consists of a molecule of glycerol joined with three fatty acids.
glycerol
a substance (also called glycerine) derived from the breakdown of triglycerides, along with fatty acids; can be converted by the liver into glucose
fatty acid
a substance derived from the breakdown of triglycerides, along with glycerol; can be metablized by most cells of the body except for the brain.
fasting phase
the phase of metablism during which nutrients are not available from the digestive system; glucose, amino acids, and fatty acids are derived from glycogen, protein, and adipose tissue during this phase
absorptive phase
the phase of metabolism during which nutrients are absorbed from the digestive system; glucose and amino acids constitute the principal source of energy for cells durigng this phase, and excess nutrients are stored in adipose tissue in the form of triglycerides
ghrelin
a peptide hormone released by the stomach that increases eating, also produced by neurons in the brain
duodenum
the first portion of the small intestine, attached directly to the stomach
glucoprivation
a dramatic fall in the level of glucose available to cells; can be caused by a fall in the blood level of glucose or by drugs that inhibit glucose metablism
lipoprivation
a dramatic fall in the level of fatty acids available to cells; usually caused by drugs that inhibit fatty acid metabolism
hepatic protal vein
the vein that transports blood from the digestive system to the liver
cholecystokinin (CCK)
a hormone secreted by the duodenum that regulates gastric motility and causes the gallbladder to contract; appears to provide a satiety signal transmitted to the brain through the vagus nerve
peptide YY 3-36 (PYY)
a peptide released by the gastrointestinal system after a meal in amounts proportional to the size of the meal
ob mouse
a strain of mice whose obesity and low metabolic rate are caused by a mutation the prevents the production of leptin
leptin
a hormone secreted by adipose tissue; decreases food intake and increases metabolic rae, primarily by inhibiting NPY-secreting neurons in the arcuate nucleus.
decerebration
a surgical procedure that serves the brain stem, disconecting the hindbrain form the forebrain
melanin-concentrating hormone (MCH)
one of two peptide neurotransmitters found in a system of latera hypothalamic neurons that stimulate appetite and reduce metabolic rate
orexin
one of two peptide neurotransmitters found in a ystem of lateral hypothalmic neurons that stimulate appedite and reduce metabolic rate. also called hypocretin
neuropeptide Y (NPY)
a peptide neurotransmiter dound in a system of neurons of the arcuate nucleus that stimulate feeding, insulin and glucorticoid secretion, decrease the breakdown of triglycerides, and decrease body temperature
arcuate nucleus
a nucleus in the base of the hypothalamus that controls secretions of the anterior pituitary gland; contains NPY-secreting neurons involved in feeding and control of metabolism
paraventricular nucleus (PVN)
a nucleus of the hypothalamus located adjacent tot he dorsal third ventricle; contains neurons involved in control of the autonomic nervous system and the posterior pituitary gland
agouti-related protein (AGRP)
a neuropeptide that acts as an antagonist at MC-4 receptors and increases eating
CART
cocain-and amphetamine-related transcript; a peptide neurotransmitter found in a system of neurons of the arcuate nucleus that inhibit feeding
a-melanocyte-stimulating hormone (a-MSH)
a neuropeptide that acts as an agonist at MC-4 receptors and inhibits eating
meanocortin-4 receptor (MC_4R)
a receptor found in the brain that binds with a-MSH and agouti-related protein; plays a role in conrol of appetite.
uncoupling protein (UCP)
a mitochrondrial protein that facilitates the conversion of nutrients into heat