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42 Cards in this Set
- Front
- Back
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What drug causes Hemorrhagic cystitis?
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Cyclophosphamide
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Antidote to an "overdose" of Cyclophosphamide?
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hydration, Mesna, NAC
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Carmustine treats what?
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Brain Tumors
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common adverse effects in anticancer drugs?
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NV, BMD, mucositis, stomatitis
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Drug used in the treatment of bladder, ovarian, and testicular cancer
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Cisplatin
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In order to improve efficacy of Cisplatan what should you do?
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Chloride diuresis
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Cisplatan "overdose" antidote?
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amifostine
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MOA of Methotrexate?
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Folate inhibitor
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Methotrexate used to treat?
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Lymphoma, leukemia, breast CA, Psoriasis, RA
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used in the "overdose" of Methotrexate?
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Leucovorin Rescue
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5-Fluorouracil used to treat?
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Basal cell carcinoma
breast cancer colorectal CA |
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Cytarabine (ara-C) must be converted to active form. What other anticancer drug is a prodrug?
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cyclophosphamide
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6-Mercaptopurine used to treat?
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ALL, AML, CML
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Vincristine used to treat?
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Lymphocytic leukemia
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Vincristine tox?
Vinblastine tox? |
CNS
myelodepression |
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Etoposide MOA
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inhibits Topoisomerase II
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Topotecan MOA
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inhibits topoisomerase I
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Dactinomycin adverse effects?
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Proctitis
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Causes Cardiotoxicity
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Doxrubicin
Daunorubicin |
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L-asparginase used to treat?
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ALL
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L-asparginase can cause what if infused rapidly?
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Anaphylaxis
also causes pancreatitis and coagulopathy |
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Tamoxifen used to treat?
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ER (+) Breast CA
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Anastrozole treats?
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mets ER (+) and PR (+) tumors
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Bortezomib treats?
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Multiple Myeloma
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Imatinib treats?
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CML
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Trastuzumab treats?
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Breast CA ER (-) but HER-2 receptor (+)
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What drug blocks VEGF?
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Bevacizumab
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Adverse Effect is Osteoporosis with long term use
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Prednisone
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what protein plays a role in multidrug resistance anticancer drugs
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p-glycoprotein= efflux pump
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what drugs Tx acute rejection episodes?
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Prednisone, ALG, muromunab-CD3, Daclizumab, Basiliximab
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This drug causes cytokine storm in a transplant patient
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Muromunab-CD3 (OKT3)
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Repeated treatments of OKT3 contraindicated why?
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Abs will form against OKT3
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What drug do you need to be careful with in transplant patients when dosing with allopurinol?
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Azothioprine
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What drug inhibits calcineurin?
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Cyclosporine
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Most common tox of cyclosporine?
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Nephrotox
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What drug causes gingival hyperplasia and hirsutism?
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cyclosporine
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What immunosupressive drug has good antiinflammatory properties?
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Azathioprine
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What drugs Treat Psoriasis, RA, and GVHD?
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Cyclosporine and Methotrexate.
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What drug is an IL-2 antagonist
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Daclizumab and Basiliximab
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Prednisone has immunosupressive properties and used for what other Tx?
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Autoimmune Dz
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major risk factors for immunosuppressive therapy?
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infection and malignancy
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Bleomycin uniqueness
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doesn't suppress BM so can be a good combo drug and causes radical testicular cancer cure
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