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8 Cards in this Set
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α2γ2
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HbF, Fetal Hemoglobin
Synthesized in fetal liver starting at the end of the 1st trimester Vast majority of hemoglobin in newborn, gradually replaced over first 6 mos. no β subunits = no charged histidine residues which interact with 2,3 BPG → HbF has stronger affinity for O2 than maternal |
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HbF
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α2γ2
HbF, Fetal Hemoglobin Synthesized in fetal liver starting at the end of the 1st trimester Vast majority of hemoglobin in newborn, gradually replaced over first 6 mos. no β subunits = no charged histidine residues which interact with 2,3 BPG → HbF has stronger affinity for O2 than maternal |
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α2δ2
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Hemoglobin A2
α2δ2 (alpha 2 delta 2) Normal variant, 5% of adult hemoglobin |
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Hemoglobin A2
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alpha2 delta2
Normal variant, 5% of adult hemoglobin |
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Hemoglobin Gower
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ζ2ε2 zeta2 epsilon2
earliest hemoglobin found in fetus synthed by yolk sac |
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ζ2ε2
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Hemoglobin Gower
zeta2 epsilon2 earliest hemoglobin found in fetus synthed by yolk sac replaced by Hemoglobin Portland (zeta2 gamma2) |
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γ4
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Hemoglobin Bart
homozygous alpha thalassemia when no alpha chains can be synthed very high affinity for O2, does not release → ts hypoxia, hydrops fetalis → fetal death |
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Hemoglobin Bart
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γ4
homozygous alpha thalassemia when no alpha chains can be synthed very high affinity for O2, does not release → ts hypoxia, hydrops fetalis → fetal death |
