Board Review: Immunology

transcription factor which induces cytokine prodxn in response to microbial infx

[Nucleotide Binding Oligomerization Domain]

intracellular microbial receptor which which triggers NF- κB transcription factor → cyokine prodxn

Epinephrine

Blood Types A & B usually have IgM anti-B & anti-A

Mom w/ Blood Type O often has IgG anti-A and anti-B

Mom with blood type O more likely to have hemolytic dz for baby than otherwise

Major Basic Protein

Kills helminths
damages epithlium

inhibit PLA2
inhibit phagocytosis
inhibit IL1 prodxn

impaired "Clonal deletion" of activated T's by CTL's in peripheral ts

indicative of combined T and B cell deficiency (SCID)

IgA deficiency

IgA deficiency

Requires interaction of B cell CD40 and T cell CD40L (CD154)

Once you go on to the next you cannot come back

M D G E A

Requires interaction of B cell CD40 and T cell CD40L (CD154)

Once you go on to the next you cannot come back

M D G E A

only found in secretions never in blood

only found in secretions never in blood

humoral response instead of T cell response because they can't actually infect cells, so they never get expressed on MHC I so they never induce mCD8T's

CD40 is a receptor on the B cell for CD154 aka CD40L on T cells

This interaction allows for class switching to occur

HLA Class I = MHC Class I
large α, β2 microglobulin

Includes HLA-A, HLA-B & HLA-C

HLA Class II = MHC Class II
Equal sized α and βglobulins

Inclues HLA-DR, HLA-DP and HLA DQ

Cholera
Anthrax
Pertussis
Plague

BCG: tuberculosis
thyphoid vaccine
Tularemia

Pneumococcus
Hib
Meningococcus

IgA cannot trigger complement cascade

only IgM and IgG

too much IgA leaves pts vulnerable to Neisseria by blocking IgG and IgM from epitopes

produced by TH2 and inhibits the synthesis of IFNγ

polyribosysl-ribitol-phosphate (PRP) - polysaccharide conjugated with protein toxoid from either diphtheria or tetanus

this allows for T cell processing and the production of memory humoral immunity in children under age 18 mo

may be given as early as 2 mo

polyribosysl-ribitol-phosphate (PRP) - polysaccharide conjugated with protein toxoid from either diphtheria or tetanus

this allows for T cell processing and the production of memory humoral immunity in children under age 18 mo

may be given as early as 2 mo

unencapsulated

commensural

unencapsulated

commensural

capsular antigen of Hib

polyribosysl-ribitol-phosphate (PRP) - polysaccharide conjugated with protein toxoid from either diphtheria or tetanus

this allows for T cell processing and the production of memory humoral immunity in children under age 18 mo

may be given as early as 2 mo

capsular antigen of Hib

polyribosysl-ribitol-phosphate (PRP) - polysaccharide conjugated with protein toxoid from either diphtheria or tetanus

this allows for T cell processing and the production of memory humoral immunity in children under age 18 mo

may be given as early as 2 mo

Antibody-dependent cytotoxicity

Eosinophils have an IgE Fx

degranulation releases major basic protein

eosinophils also contain histaminase which degraes histamine and decreases severity of atopy also leukotrienes and peroxidases which ↑ inflammation

Myeloperoxidase is a blue green heme based pigmented molecule within the azurophilic granules of PMN's which catalyzes the prdxn of HOCl from h2O2

Monocyte-M∅ lineage

Splenectomy

vulnerable to encapsulated organisms

Pneumococcus
Meningococcus
H influenzae