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48 Cards in this Set

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cimetiDINE
"take H2 before you DINE"

H2 Blocker
ranitiDINE
"take H2 before you DINE"

H2 Blocker
famotiDINE
"take H2 before you DINE"

H2 Blocker
nizatiDINE
"take H2 before you DINE"

H2 Blocker
Omeprazole
PPI (Inhib H/K ATPase)
Lansoprazole
PPI (Inhib H/K ATPase)
Which 2 Drugs does this describe?

-Bind to ulcer base --> Physical protection

-allow HCO3- secretion to reestablish pH gradient in stomach mucous layer

-Promotes ulcer healing

-Used for traveler's Diarrhea
Bismuth
Sucralfate
What Rx does this describe:

-PGE2 analog
-Inc gastric mucous barrier
-Dec gastric acid production

-P-laxes NSAID induced peptic ulcers
-Can induce labor
-Maintains a patent DA
Misoprostol
Octreotide
Somatostatin Analog that inhibs products of ant pituitary
3 diff types of Antacids?
Aluminum Hydroxide
Mg Hydroxide
Ca Hydroxide
Which antacid does this describe:

-constipation
-hypophosphatemia
-prox muscle weak
-osteodystrophy
-seizures
Al Hydroxide
Which antacid does this describe?

-Diarrhea
-Hyporeflexia
-Hypo-TN
-Cardiac arrest
Mg Hydroxide
Which antacid does this describe?

-Hypercalcemia
-Rebound Inc Acid
Ca Carbonate
What kind of drugs are the following?

-Mg OH
-Mg Citrate
-Polyethylene glycol
-Laculose
Osmotic Laxitives
Infliximab

MOA?
CU?
Monoclonal Ab for TNF

Crohn's Dz
RA
Which Rx has the following characteristics:

-Used for ulcerative colitis
-Used for Crohn's Dz
-1st Choice for RA in preggos
sUlfasalazine
What is the name of a strong 5-HT3 ANTAGONIST that is a powerful anti-emetic?
Odansetron
Metoclopramide
"the METS ANTAGONIZE me. these PROS make me VOMIT. sometimes they play ball @ the PARK

-D2 receptor Antag
-Prokinetic (inc resting tone, contractility, LES sphincter tone, motility)
TF
used for gastroparesis
-Used for n/v
-Has parkinsonian FX
GI Drugs
GI Drugs
MOA of cimetidine, Ranitidine, Famotidine, Nizatidine?
H2 blockers --> Dec HCl secretion by parietal cells
These drugs can be used for peptic ulcer, gastritis, esophageal reflux
H2 Blockers (-dines)
Which H2 blocker is a potent inhibitor of P-450 and has antiandronergic FX --> gynecomastia and impotence)?
Cimetidine
Name 2 PPIs (Inhib H/K ATPase)
Omeprazole, Lansoprazole
What class of drugs are used for the following:
Zollinger-Ellison syndrome,
Peptic Ulcer,
Gastritis,
Esophageal Reflux
PPIs (-prazoles)
These 2 drugs will bind to peptic ulcer base, providing physican protection
AND
allow HCO3- secretion to reestablish pH gradoent
Bismuth
Sucralfate
2 CUs of Bismuth and sucralfate?
Inc ulcer healing
Traveler's Diarrhea
PGE analog that increases gastric mucous barrier and decreases acid produciton
MisoPROSTol
P-laxes what?

Maintains what?

1 other use of MisoPROStol
NSAID-induced peptic ulcers

Patent Ductus Arteriosus

Induces labor
MisoPROStol is CI'ed in preggos, why?
Induces aboriton (Abortifacient)
Which drug is a Somatostatin analog?
Octreotide
What drug has the following CU:
Acute variceal bleed, acromegaly, VIPoma, Carcinoid tumor
Octreotide
1 AE of octreotide?
Steatorrhea
3 Antacids?
AlOH
MgOH
Ca-Carbonate
Which of the antacids has the following AEs?:

Constipation;
Hypophosphatemia;
Prox muscle weak;
Osteodystrophy;
Seizures
AlOH
Which Antacid has the following AEs:
Diarrhea, hyporeflexia, hypo-TN, cardiac arrest
MgOH

Diarrhea: Must Go to the bathroom
Which antacid has the following AEs:
Hypercalcemia, Rebound Increase in Acid
Calcium Carbonate
All antacids can cause what?
Hypokalemia
Name 4 osmotic laxitives

MOA?
MgOH, Mg Citrate, Polyethylene Glycol, Lactulose

Pull H2O into gut by being osmotically active in the gut
Lactulose can also tx what?
Hepatic encephalopathy -
Gut bacteria degrade it into metabolites and promote nitrogen excretion as NH4
CU of osmotic laxitives?
Constipation
3 AEs of osmotic laxitives?
Diarrhea
Dehydration
Can be abused by bulimics
Monoclonal Ab that can be used for Crohn's Dz and RA?
Infliximab
1 AE of infliximab?
Inc susceptibility to TB Infxn
What drug is a combo of sulfapuridine and 5ASA and is activated by gut bacteria?
Sulfasalazine
CU of sulfasalazine?

1 AE of sulfasalazine for males?
UC, Crohn's

Reversible oligospermia
What GI drug is a 5-HT (Serotonin) antag that is a POWERFUL anti-emetic?

Odansetron's anti-emetic props make it a good drug for who?
Odansetron

CA pts undergoing chemo who are vomitting
Which GI drug is a D2 receptor antag?

MOA of Metoclopramide?
Metoclopramide

Pro-kinetic and anti-emetic
CU of metoclopramide?

Major AE of metoclopramide?
Gastroparesis, N/V

Parkinson's