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19 Cards in this Set
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- Back
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6 immunosuppressants you should see pic for
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Daclizumab
Muronamab Tacrolimus Azathioprine Cyclosporine Sirolimus |
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Daclizumab
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Monoclonal Ab that antags T-cell IL2 Recept -->
dec diff & activation of T-cells |
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Muromonab
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Monoclonal Ab that antags CD3 on T-cell -->
no diff & activation of T-cells |
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Tacrolimus
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Binds FK-binding PRO -->
Dec secretion of IL-2 |
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Azathioprine
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Metab'd to 6-mercaptopurine which inhibs Nucleic Acid Synth -->
No Diff & Activation of T-cells |
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Cyclosporine
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Binds cyclophilin-->
Cyclosporine - Cyclophilin inhibs calcineurin --> no synth of IL-2 & its Receptor --> No diff & activation of T-cells |
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Sirolimus
(Rapamycin) |
Inhibs mTOR -->
No T-cell diff & activation in response to IL-2 |
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More Misc Immuno Pharm That you didn't pick up last time
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More Misc Immuno Pharm That you didn't pick up last time
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What Immunosuppresant does this describe:
-Suppresses organ rejection after transplantation -Predisposes pts to viral infxns and lymphomas -Nephrotoxicity that is preventable w/ mannitol diuresis -May cause gout |
Cyclosporine
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What immunosuppressant binds to cyclophilins --> a complex that inhibits calcineurin?
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Cyclosporin
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What immunosuppressant:
-is used in organ t-plant -can cause: nephrotoxicity, periph neuropathy, HTN, pleural effusion and hyperglycemia |
Tacrolimus
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Which immunosuppressant binds an FK-binding PRO --> Inhibition of secretion of IL-2 for T-cells.
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Tacrolimus
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Which immunosuppressant inhibits mTOR in T-cells?
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Sirolimus (Rapamycin)
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Which immunosuppressant is good to use after kidney T-plant w/ cyclosporine and corticosteroids?
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Sirolimus (rapamycin)
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Which immunosuppressant is a monoclonal Ab w/ a high affinity for IL-2 Receptor on activated T-cells?
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Daclizumab
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Which immunosuppressant is a pro-drug?
MOA? |
Azathioprine
Metab'd to 6-mercaptopurine --> Inhib of Nucleic Acid synth in T-cells |
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Since Azathioprine --> 6-mercaptupurine by xanthine oxidase, it's toxic FX may be increased by co-administration of what xanthine oxidase inhibitor?
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Allopurinol
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This immunosuppressant can cause Bone Marrow suppression?
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Azathioprine
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This Rx is a monoclonal Ab that binds CD3 on T-cells that can be used for immunosuppression after kidney transplantation?
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Muronomab
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