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6 Cards in this Set
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Which group of drugs works to block ACh receptors in the nervous system? What happens during an OD of this group? What is the antidote?
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Anticholinergics (ie, atropine, ipratropium)
Dry as a bone (anhidrosis), Mad as a hatter (delerium), blind as a bat (mydriasis), hot as a hare (fever) Physostigmine is the antidote |
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What group of drugs inhibits cholinesterase (over-abundance of ACh) which can produce an over stimulation of skeletal muscle and parasympathetic nervous system? What are the OD symptoms? What is the antidote
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Organophosphates
Salivation, Lacrimation, Urination, Defecation, GI upset, Emesis (SLUDGE) Atropine is the antidote |
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What is the action of Aminoglycosides? Vancomycin? Quiniolones? Chloramphenicol? Erythromycin? Tetracycline? Sulfonamides? Trimethoprim?
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A - inhibit initiation of translation (Aerobic, Gram neg)
V - inhibits cell membrane and cell wall synthesis (DOC MRSA) Q - inhibit topoisomerase so can't use own DNA C - inhibits peptidyl transferase necessary for protein synthesis (protein synth inhibitor) E - protein synthesis inhibitor Tetra - inhibits protein synthesis S - inhibit folate synthesis Tri - inhibit folate synthesis |
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What is the action of Bacitracin? Polymyxin? Carbapenems? Glycopeptides? Clindamycin? Metronidazole? Nitrofurantoin?
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B - inhibits cell wall synthesis topically
P - antipseudomonal agent - topical, ophthalmic C - powerful cell wall cynthesis inhibitors (most gram pos and many gram neg, both anaerobic and aerobic) G - cell wall synthesis inhibitors (only gram pos that are very serious) clinda - protein synthesis inhibitor M - activates mechanisms that destroy microbial DNA (anerobic bacteria/protozoa) N - accumulates in urine - goof for UTI/DOC in preggo UTI) |
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What is Empirical Treatment?
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treatments that are done before the culture results are available and/or before the eitiologic agent is known
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What is Drug of Choice?
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preferred drug to use AFTER the specific microbial causative agent has been identified.
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