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37 Cards in this Set

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What is Watson's syndrome?
Variant of NF1
Multiple CALM
Short stature
Pulmonary valve stenosis
Small number of NF
HLA associated with carbamazepine-induced SJS
HLA B1502
HLA associated with abacavir-induced hypersensitivity syndrome
HLA B5701
HLA associated with allopurinol-induced SJS
HLA B5801
Causes of SJS/TEN
Allopurinol
Sulfonamides
Aromatic anticonvulsants (carbamazepine, phenytoin, phenobarb)
oxicam NSAIDs
Nevirapine
Lamotrigine
Drug-induced vasculitis
Small vessel vasculitis
Usually present with palpable purpura
Rare mucosal involvement
Joints, kidneys, GI tract
Less commonly CNS, lungs
Antibiotics, Thiazides, furosemide, PTU, phenytoin
Drug-induced pANCA positive vasculitis
hydralazine
PTU
allopurinol
Rarely minocin
Induce GN, upper respitory tract disease, pulmonary hemorrhage
Offending agents in drug hypersensitivity reaction
Aromatic anticonvulsants
Lamotrigine
Sulfonamides
Dapsone
Minocycline
Abacavir
Allopurinol
MC drugs to cause AGEP
Macrolides
beta-lactam antibiotics
Quinolones
Also terbinafine, ditiazem, hydroxychloroquine
Pathogenesis of AGEP
T cell mediated
IL8 produced by drug-specific CD4 T cells results in influx of PMN's
Clinical Features of drug hypersensitivity reaction
Facial edema in anticonvulsant mediated reations
Fever, pharyngitis, LAD
Leukocytosis w/ eosinophilia and/or atypical lymphs and hepatitis
Delayed hypothyroidism
Meds in drug-induced erythroderma
Gold
Pyrazolone derivatives
Phenytoin
Dapsone
Lithium
Drug-induced oral hyperpigmentation
antimalarials: blue-gray of palate
Bismuth, lead intoxication: narow band of blue-black along marginal gingiva
Minocin: discolors bone, teeth, ral mucosa
Drug-induced gingival hyperplasia
Phenytoin
Cyclosporine
CCB: nifedipine, verapamil, amlodipine
Azithromycin may decrease cyclosporine-induced gingival hyperplasia
Types of dysphagia in DM
1) Proximal: striated muscle in pharynx or proximal esophagus
Correlates w/ severity of muscle disease
Corticosteroid responsive
2) Distal: Poor progrnosis, associated pulmonary involvement
Paraneoplastic DM
GU: ovarian
Lung, pancreatic, colon, NHL, breast CA
Autoantibodies in juvenile DM
anti-MJ
anti-PMS1
Myositis-overlap syndrome autoantibodies
u1RNP
Ku
PM-Scl
Antibodies in amyopathic DM
Anti-CADM-140
Lack of anti-Jo1 even w/ pulmonary involvemen
Ab in malignancy-associated myositis
anti-p155
anti-p155/p140
What is the most classic ocular lesion seen in Behcet's?
posterior uveitis (retinal vasculitis)
What is the most common type of psoriatic arthritis?
Asymmetric oligoarticular
What lab test is more specific for RA than rheumatoid factor but less sensitive?
anti-cyclic citrullinated peptide (CCP)
What determines hair length?
rate and duration of anagen phase
Functional types of telogen effluvium
Immediate anagen release (drugs, physiological stressors)
Delayed anagen release (due to prolonged anagen; postpartum)
Short anagen (inc. shedding, can't grow long hair)
Immediate telogen release
Delayed telogen phase
Two conditions (not genodermatoses) associated with poikiloderma?
dermatomyositis
CTCL (favors axillae and groin)
Most frequent site of visceral disease in KS?
GI
Chromosome translocation in mantle cell lymphoma
t(11;14)
Chrmmosome translocation in follicular lymphoma
t(14;18)
Chromosome translocation in Burkitt's lymphoma?
t(8;14)
Granulomatous slack skin is associated with increased risk of which neoplasms?
NHL and Hodgkin's
Antibodies found in SJS?
desmoplakin 1 and 2
Name for atypical lymphocytes in Rubella?
Turk cells
Helpful immunohistochemical stain to distinguish primary from metastatic skin tumors?
p63 (expressed by most benign & malignant primary skin tumors)
Also: B72.3, calreticulin, CK 5/6
Immunohistochemical stain to differentiate RCC from skin primaries of eccrine or apocrine origin?
CD10 positivity favors RCC
systemic disease associated with xanthoma striatum palmare (besides hyperlipoproteinemia)
primary biliary cirrhosis
Systemic disease associated with diffuse planar xanthomas
paraproteinemias, esp multiple myeloma