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12 Cards in this Set

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Rejection Grading
0R
1R
2R
4R
0R
No Rejection = 1990 (Grade 0)
1R Mild 2004
Interstitial and/or perivascular infiltrates with up to 1 focus of myocardial damage
1990 = 1A,1B, 2 (myocyte damage)
2R moderate 2004
2 or more foci of infiltrate with association w/myocyte damage

1990 Grade 3 A -focal
3R Severe
Diffuse infiltrate w/multifocal myocyte damage, +/- edema, hemorrhage, vasculitis
1990 Grade 3B, 4
Hyperacute rejection
hemorrhage , edema, plt aggregates in blood vessels, with time polys.
Acute rejection
lymphocytes, macrophages, eos
No neuts
No plasma cells (Quilty or PTLD)
Eos
Toxo, CMV, drug rxn
Acute antibody mediated rejection
capillary injury, endothelial swelling & intravascular macrophages
Edema, hemorrhage, neutrophils near capillaries, thrombi & myocyte necrosis
Quilty Lesion
Dense lymphocytes within the endocardium,
b+T cells
cyclosporin, one piece of tissue
Endocarditis
Bacterial-friable vegetations
Marantic - small attached to lines of closure-valve surface
Limban - Sacks - SLE - both surfaces - T>M>P>A
RHD
RF - Grp A strep (Beta-hemolytic)
Aschoff Nodules-Aschoff giant cell
Anitschkow cells - mononuclear histiocytes - arranged in a palasade around the center of a granuloma
Mitral stenosis - fishmouth