- Shuffle
Toggle OnToggle Off
- Alphabetize
Toggle OnToggle Off
- Front First
Toggle OnToggle Off
- Both Sides
Toggle OnToggle Off
Front
How to study your flashcards.
Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key
Up/Down arrow keys: Flip the card between the front and back.down keyup key
H key: Show hint (3rd side).h key
PLAY BUTTON
PLAY BUTTON
28 Cards in this Set
- Front
- Back
|
Brain metabolism is based almost entirely on the oxidation of
|
glucose
|
|
The Major use of glucose metabolism is expended in?
|
maintenance of membrane potentials
(primarily via the Na-K ATPase pump) |
|
Minor use of glucose metabolism is for?
|
Neurotransmitter synthesis (gluamate, GABA, Acetylcholine) and glycoprotein and glycolipid synthesis
|
|
Na+/K+ ATPase is particularly active in
|
Astrocytes
|
|
Na+/K+ ATPase is particularly active in Astrocytes and stimulated by
|
glutamate
|
|
Anoxia or metabolic poisons can result in?
|
membrane depolarization
(often resulting in seizure activity) |
|
The major interface for the transport of glucose from blood to neurons?
|
Astrocytes
|
|
Can act as a reservoir for glycogen
|
Astrocytes
|
|
Can also act as a carbohydrate source for brain metabolism but is not commonly available and is absorbed slower?
|
Mannose
|
|
_____can become an energy source for the brain under conditions of neonatal sucking, diabetes, starvation and low carb intake
|
Ketone Bodies
|
|
_____ appears to be an energy source released by Astrocytes at the synaptic level.
|
Lactate
|
|
Lactate is stimulated to be released by astrocytes via the release of?
|
Glutamate
|
|
2/3 of the vascular resistance is attributed to the ________ and the remaining 3rd controlled within the __________
|
1. pial vessels
2. vascular tissue beds |
|
under normal circumstances cerebral blood flow is TIGHTLY coupled to
|
metabolism
|
|
Increase in neuronal activity are rapidly accompanied by:
|
vasodilation and increase blood flow
|
|
The end regulators in metabolism being tightly coupled to cerebral blood flow are?
|
1. Nitrous Oxide
2. Adenosine |
|
Adenosine can be produced in association with ATP utilization and causes
|
vasodilation
|
|
What is the most potent regulator of the resistance of cerebral capillary beds?
|
Carbon Dioxide
|
|
Carbon Dioxide produces changes in hydrogen ion concentration in perivascular fluid which in turn activates
|
Mediators NO and Adenosine
|
|
Hypercapnia
|
increase in CO2 --> vessel dilate
|
|
Hypocapnia
|
decreased CO2 - Vessel Constrict
|
|
Astrocytes play a role in the regulation of cerebral blood flow through mechanisms related to
|
Calcium regulation and arachidonic acid metabolites
|
|
Mechanical (myogenic) autoregulation of blood flow is related to
|
intraluminal pressure (arterial blood pressure)
|
|
_________ is the most abundant perivascular neurotransmiteer
|
Acetylcholine
|
|
The Primary anatomical substrates for the blood brain barrier include:
|
1. Tight Junction
2. Pervascular cells 3. Basement membrane 4. Astrocytic endfeet that surround cerebral capillaries |
|
Permeability of the blood-brain barrier is inversely proportional to
|
molecular size
|
|
permeability of the blood-brain barrier is directly proportional to
|
lipid solubility
|
|
the blood brain barrier generally does not allow the passage of
|
plasma proteins or drugs that are bound to them
|
