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17 Cards in this Set
- Front
- Back
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Bethanechol mechanism of action
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direct acting muscarinic agonist
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Carbachol mechanism of action
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direct acting muscarinic and nicotinic agonist
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Pilocarpine mechanism of action
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direct acting muscarinic agonist
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Physostigmine mechanism of action
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reversible AChE inhibitor
acts on muscarinic and nicotinic receptors |
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Neostigmine mechanism of action
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reversible AChE inhibitor
acts on muscarinic and nicotinic receptors |
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Edrophonium mechanism of action
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reversible AChE inhibitor
acts on muscarinic and nicotinic receptors *brief duration of action |
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Pyridostigmine mecanism of action
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reversible AChE inhibitor
acts on muscarinic and nicotinic receptors |
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Organophosphate mechanism of action
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irreversible AChE and pseudocholinesterase inhibitor
*used as pesticide, easily causes death |
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Atropine mechanism of action
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competitive muscarinic antagonist
binds to receptor sites on effector organ to prevent ACh binding *may be overwhelmed by high levels of ACh |
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Glycopyrrolate mechanism of action
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muscarinic antagonist
longer duration of action than atropine *fewer CNS side effects b/c does not cross BBB well |
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What effects do muscarinic agonists have?
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decrease HR
decrease or no effect on BP increased secretions (SLUDD) miosis |
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What effects do nicotinic agonists have?
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muscle contraction, twitches
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where are nicotinic receptors?
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somatic NS (skeletal muscle)
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where are muscarinic receptors?
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autonomic NS (parasympathetic)
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what does SLUDD stand for?
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salivation, lacrimation, urination, defecation, death
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what do direct acting cholinergic agonists bind to?
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receptors on target
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what do indirect acting cholinergic agonists bind to?
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AChE or pseudocholinesterase
cause decreased breakdown of ACh |
