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7 Cards in this Set
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t(9;22)
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CML
bcr-abl hybrid |
Translocation of the two chromosomes creates the Philadelphia chromosome, which codes for a pathologic fusion protein (tyrosine kinase). The protein is constitutively active and activates a number of cell cycle-controlling enzymes, effectively speeding up cell division. It also inhibits DNA repair. |
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t(8;14)
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Burkitt's lymphoma
c-myc activation |
Places c-myc (transcription factor - protooncogene) under transcriptional control of the Ig heavy-chain promotor, which leads to overexpression |
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t(14;18)
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Follicular lymphoma
bcl-2 activation |
Places bcl-2 (anti-apoptosis) under transcriptional control of the Ig heavy-chain promotor, which leads to overexpression |
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t(15;17)
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AML - M3
responsive to all-trans retinoic acid |
The gene for the retinoic acid receptor (17) is transferred to be adjacent to the PML gene (15). Codes for a pathologic fusion protein that creates an abnormal retinoic acid receptor, and this inhibits myloblastic differentiation. This is why this leukemia can be treated with vitamin A. |
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t(11;22)
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Ewing's sarcoma
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t(11;14)
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Mantle cell lymphoma
Overexpression of cyclin D regulatory protein |
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t(12;21)
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ALL with best prognosis
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